Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer

BACKGROUND: Triple-negative breast cancer (TNBC), lacking expression of hormone and human epidermal growth factor receptor 2 receptors, is an aggressive subtype that frequently metastasizes to the brain and has no FDA-approved systemic therapies. Previous literature demonstrates mitogen-activated pr...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Van Swearingen, Amanda E D, Sambade, Maria J, Siegel, Marni B, Sud, Shivani, McNeill, Robert S, Bevill, Samantha M, Chen, Xin, Bash, Ryan E, Mounsey, Louisa, Golitz, Brian T, Santos, Charlene, Deal, Allison, Parker, Joel S, Rashid, Naim, Miller, C Ryan, Johnson, Gary L, Anders, Carey K
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737524/
https://ncbi.nlm.nih.gov/pubmed/28486691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox052
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