טוען...
PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition
BACKGROUND: Glioblastoma (GBM) is the most common adult primary brain tumor. Multimodal treatment is empiric and prognosis remains poor. Recurrent PIK3CA missense mutations (PIK3CA(mut)) in GBM are restricted to three functional domains: adaptor binding (ABD), helical, and kinase. Defining how these...
שמור ב:
| הוצא לאור ב: | PLoS One |
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| Main Authors: | , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Public Library of Science
2018
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6033446/ https://ncbi.nlm.nih.gov/pubmed/29975751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200014 |
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