PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition

BACKGROUND: Glioblastoma (GBM) is the most common adult primary brain tumor. Multimodal treatment is empiric and prognosis remains poor. Recurrent PIK3CA missense mutations (PIK3CA(mut)) in GBM are restricted to three functional domains: adaptor binding (ABD), helical, and kinase. Defining how these...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: McNeill, Robert S., Stroobant, Emily E., Smithberger, Erin, Canoutas, Demitra A., Butler, Madison K., Shelton, Abigail K., Patel, Shrey D., Limas, Juanita C., Skinner, Kasey R., Bash, Ryan E., Schmid, Ralf S., Miller, C. Ryan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033446/
https://ncbi.nlm.nih.gov/pubmed/29975751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200014
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