DRES-08. DYNAMIC KINOME PROFILING OF GENETICALLY-DEFINED, EGFRvIII-DRIVEN MURINE ASTROCYTE MODELS OF GLIOBLASTOMA REVEALS TARGETS FOR DUAL KINASE INHIBITOR THERAPY

Glioblastoma (GBM) has poor survival and lacks effective treatments. Due to frequent amplification and mutation of epidermal growth factor receptor (EGFR), several EGFR tyrosine kinase inhibitors have been trialed, but none have proven successful. One potential reason for failure is acquired resista...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Smithberger, Erin, Shelton, Abigail, Butler, Madison, Flores, Alex, Bash, Ryan, Angus, Steven, Sciaky, Noah, Dhruv, Harshil, Johnson, Gary, Berens, Michael, Furnari, Frank, Miller, Ryan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2018
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Abstracts
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216460/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.315
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