DRES-08. DYNAMIC KINOME PROFILING OF GENETICALLY-DEFINED, EGFRvIII-DRIVEN MURINE ASTROCYTE MODELS OF GLIOBLASTOMA REVEALS TARGETS FOR DUAL KINASE INHIBITOR THERAPY

Glioblastoma (GBM) has poor survival and lacks effective treatments. Due to frequent amplification and mutation of epidermal growth factor receptor (EGFR), several EGFR tyrosine kinase inhibitors have been trialed, but none have proven successful. One potential reason for failure is acquired resista...

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Publicat a:Neuro Oncol
Autors principals: Smithberger, Erin, Shelton, Abigail, Butler, Madison, Flores, Alex, Bash, Ryan, Angus, Steven, Sciaky, Noah, Dhruv, Harshil, Johnson, Gary, Berens, Michael, Furnari, Frank, Miller, Ryan
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216460/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.315
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