DRES-07. DEFINING THE MECHANISMS OF ACQUIRED RESISTANCE TO TYROSINE KINASE INHIBITORS IN EGFR-DRIVEN GLIOBLASTOMAS USING INTEGRATED KINOME AND TRANSCRIPTOME PROFILING

Glioblastoma (GBM), the most common and malignant adult primary brain tumor, has been extensively molecularly characterized. Two mutations occur at particularly high frequency: CDKN2A deletion (50–60%) and EGFR (40–50%), especially EGFRvIII (~35%) in which exons 2–7 are deleted and result in constit...

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Publicado no:Neuro Oncol
Main Authors: Shelton, Abigail, Smithberger, Erin, Butler, Madison, Flores, Alex, Bash, Ryan, Angus, Steven, Sciaky, Noah, Dhruv, Harshil, Johnson, Gary, Berens, Michael, Furnari, Frank, Miller, Ryan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216447/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.314
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