DRES-07. DEFINING THE MECHANISMS OF ACQUIRED RESISTANCE TO TYROSINE KINASE INHIBITORS IN EGFR-DRIVEN GLIOBLASTOMAS USING INTEGRATED KINOME AND TRANSCRIPTOME PROFILING

Glioblastoma (GBM), the most common and malignant adult primary brain tumor, has been extensively molecularly characterized. Two mutations occur at particularly high frequency: CDKN2A deletion (50–60%) and EGFR (40–50%), especially EGFRvIII (~35%) in which exons 2–7 are deleted and result in constit...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Neuro Oncol
Κύριοι συγγραφείς: Shelton, Abigail, Smithberger, Erin, Butler, Madison, Flores, Alex, Bash, Ryan, Angus, Steven, Sciaky, Noah, Dhruv, Harshil, Johnson, Gary, Berens, Michael, Furnari, Frank, Miller, Ryan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Oxford University Press 2018
Θέματα:
Abstracts
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216447/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.314
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