The Pharmacological Landscape and Therapeutic Potential of Serine Hydrolases

gan Bachovchin, Daniel A., Cravatt, Benjamin F.
Cyhoeddwyd 2012

Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages

gan Taabazuing, Cornelius Y., Okondo, Marian C., Bachovchin, Daniel A.
Cyhoeddwyd yn Cell Chem Biol (2017)

The NLRP1 and CARD8 inflammasomes

gan Taabazuing, Cornelius Y., Griswold, Andrew R., Bachovchin, Daniel A.
Cyhoeddwyd yn Immunol Rev (2020)

Substrate-Free High-Throughput Screening Identifies Selective Inhibitors for Uncharacterized Enzymes

gan Bachovchin, Daniel A., Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F.
Cyhoeddwyd 2009

α-Lytic protease can exist in two separately stable conformations with different His(57) mobilities and catalytic activities

gan Haddad, Kristin Coffman, Sudmeier, James L., Bachovchin, Daniel A., Bachovchin, William W.
Cyhoeddwyd 2005

Rapid Development of a Potent Photo-Triggered Inhibitor of the Serine Hydrolase RBBP9

gan Liu, Xiaodan, Dix, Melissa, Speers, Anna E., Bachovchin, Daniel A., Zuhl, Andrea M., Cravatt, Benjamin F., Kodadek, Thomas
Cyhoeddwyd 2012

Click-generated triazole ureas as ultrapotent, in vivo-active serine hydrolase inhibitors

gan Adibekian, Alexander, Martin, Brent R., Wang, Chu, Hsu, Ku-Lung, Bachovchin, Daniel A., Niessen, Sherry, Hoover, Heather, Cravatt, Benjamin F.
Cyhoeddwyd 2011

DPP8/9 inhibitors are universal activators of functional NLRP1 alleles

gan Gai, Kuo, Okondo, Marian C., Rao, Sahana D., Chui, Ashley J., Ball, Daniel P., Johnson, Darren C., Bachovchin, Daniel A.
Cyhoeddwyd yn Cell Death Dis (2019)

DPP9’s Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation

gan Griswold, Andrew R., Ball, Daniel P., Bhattacharjee, Abir, Chui, Ashley J., Rao, Sahana D., Taabazuing, Cornelius Y., Bachovchin, Daniel A.
Cyhoeddwyd yn ACS Chem Biol (2019)

Potent and Selective Inhibitors of Glutathione S-transferase Omega 1 that Impair Cancer Drug Resistance

gan Tsuboi, Katsunori, Bachovchin, Daniel A., Speers, Anna E., Spicer, Timothy P., Fernandez-Vega, Virneliz, Hodder, Peter, Rosen, Hugh, Cravatt, Benjamin F.
Cyhoeddwyd 2011

Novel Inhibitors for PRMT1 Discovered by High–Throughput Screening Using Activity–Based Fluorescence Polarization

gan Dillon, Myles B. C., Bachovchin, Daniel A., Brown, Steven J., Finn, M.G., Rosen, Hugh, Cravatt, Benjamin F., Mowen, Kerri A.
Cyhoeddwyd 2012

Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome

gan Okondo, Marian C., Rao, Sahana D., Taabazuing, Cornelius Y., Chui, Ashley J., Poplawski, Sarah E., Johnson, Darren C., Bachovchin, Daniel A.
Cyhoeddwyd yn Cell Chem Biol (2018)

DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes

gan Johnson, Darren C., Okondo, Marian C., Orth, Elizabeth L., Rao, Sahana D., Huang, Hsin-Che, Ball, Daniel P., Bachovchin, Daniel A.
Cyhoeddwyd yn Cell Death Dis (2020)

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

gan Bachovchin, Daniel A., Ji, Tianyang, Li, Weiwei, Simon, Gabriel M., Blankman, Jacqueline L., Adibekian, Alexander, Hoover, Heather, Niessen, Sherry, Cravatt, Benjamin F.
Cyhoeddwyd 2010

Discovery and Optimization of Sulfonyl Acrylonitriles as Selective, Covalent Inhibitors of Protein Phosphatase Methylesterase-1

gan Bachovchin, Daniel A., Zuhl, Andrea M., Speers, Anna E., Wolfe, Monique R., Weerapana, Eranthie, Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F.
Cyhoeddwyd 2011

A chemical strategy for protease substrate profiling

gan Griswold, Andrew R., Cifani, Paolo, Rao, Sahana D., Axelrod, Abram J., Miele, Matthew M., Hendrickson, Ronald C., Kentsis, Alex, Bachovchin, Daniel A.
Cyhoeddwyd yn Cell Chem Biol (2019)

A Fluopol-ABPP HTS Assay to Identify PAD Inhibitors

gan Knuckley, Bryan, Jones, Justin E., Bachovchin, Daniel A., Slack, Jessica, Causey, Corey P., Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F., Thompson, Paul R.
Cyhoeddwyd 2010

Quantitative reactivity profiling predicts functional cysteines in proteomes

gan Weerapana, Eranthie, Wang, Chu, Simon, Gabriel M., Richter, Florian, Khare, Sagar, Dillon, Myles B.D., Bachovchin, Daniel A., Mowen, Kerri, Baker, David, Cravatt, Benjamin F.
Cyhoeddwyd 2010

Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9)

gan Bachovchin, Daniel A., Wolfe, Monique R., Masuda, Kim, Brown, Steven J., Spicer, Timothy P., Fernandez-Vega, Virneliz, Chase, Peter, Hodder, Peter S., Rosen, Hugh, Cravatt, Benjamin F.
Cyhoeddwyd 2010

Activation of the CARD8 Inflammasome Requires a Disordered Region

gan Chui, Ashley J., Griswold, Andrew R., Taabazuing, Cornelius Y., Orth, Elizabeth L., Gai, Kuo, Rao, Sahana D., Ball, Daniel P., Hsiao, Jeffrey C., Bachovchin, Daniel A.
Cyhoeddwyd yn Cell Rep (2020)