ET-35 PACRITINIB: A NOVEL JAK/STAT INHIBITOR WITH TRANSLATIONAL RELEVANCE FOR GBM

Por Luchman, Artee, Aman, Ahmed, Al-Awar, Rima, Weiss, Samuel
Publicado em 2014

Small molecules reveal an alternative mechanism of Bax activation

Por Brahmbhatt, Hetal, Uehling, David, Al-awar, Rima, Leber, Brian, Andrews, David
Publicado no Biochem J (2016)

Asymmetric Synthesis of All the Known Phlegmarine Alkaloids

Por Wolfe, Bradley H., Libby, Adam H., Al-awar, Rima S., Foti, Christopher J., Comins, Daniel L.
Publicado em 2010

Use of Kinase Inhibitors to Correct ΔF508-CFTR Function

Por Trzcińska-Daneluti, Agata M., Nguyen, Leo, Jiang, Chong, Fladd, Christopher, Uehling, David, Prakesch, Michael, Al-awar, Rima, Rotin, Daniela
Publicado em 2012

BRAIN TUMOUR INITIATING CELLS AND TARGETING STAT3 ONCOGENIC SIGNALLING IN GBM

Por Weiss, Samuel, Nguyen, Stephanie, Luchman, Artee, Grinshtein, Natalie, Stechishin, Owen, Aman, Ahmed, Uehling, David, al-Awar, Rima, Kaplan, David
Publicado em 2014

Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence

Por Ganesh, Ahil N., Aman, Ahmed, Logie, Jennifer, Barthel, Ben L., Cogan, Peter, Al-awar, Rima, Koch, Tad H., Shoichet, Brian K., Shoichet, Molly S.
Publicado no ACS Chem Biol (2019)

Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

Por Gwynne, William D., Shakeel, Mirza S., Girgis-Gabardo, Adele, Kim, Kwang H., Ford, Emily, Dvorkin-Gheva, Anna, Aarts, Craig, Isaac, Methvin, Al-awar, Rima, Hassell, John A.
Publicado no BMC Cancer (2020)

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

Por Yu, Wenyu, Smil, David, Li, Fengling, Tempel, Wolfram, Fedorov, Oleg, Nguyen, Kong T., Bolshan, Yuri, Al-Awar, Rima, Knapp, Stefan, Arrowsmith, Cheryl H., Vedadi, Masoud, Brown, Peter J., Schapira, Matthieu
Publicado no Bioorg Med Chem (2013)

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma

Por Babichev, Yael, Kabaroff, Leah, Datti, Alessandro, Uehling, David, Isaac, Methvin, Al-awar, Rima, Prakesch, Michael, Sun, Ren X., Boutros, Paul C., Venier, Rosemarie, Dickson, Brendan C., Gladdy, Rebecca A.
Publicado no J Transl Med (2016)

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells

Por Rotin, Lianne E., MacLean, Neil, Aman, Ahmed, Gronda, Marcela, Lin, Feng-Hsu, Hurren, Rose, Wang, XiaoMing, Wrana, Jeffrey L, Datti, Alessandro, Al-awar, Rima, Minden, Mark D., Schimmer, Aaron D.
Publicado no Haematologica (2016)

Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K

Por Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong-Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al-awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad
Publicado no EMBO Mol Med (2014)

ATPS-28 COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS

Por Grinshtein, Natalie, Rioseco, Constanza, Uehling, David, Aman, Ahmed, Luchman, Artee, Senger, Donna, Robbins, Steve, Cairncross, Greg, Datti, Alessandro, Wrana, Jeff, Jones, Steve, Marra, Marco, Moran, Mike, Al-awar, Rima, Weiss, Samuel, Kaplan, David
Publicado no Neuro Oncol (2015)

Prevalent p53 mutants co-opt chromatin pathways to drive cancer growth

Por Zhu, Jiajun, Sammons, Morgan A., Donahue, Greg, Dou, Zhixun, Vedadi, Masoud, Getlik, Matthaeus, Barsyte-Lovejoy, Dalia, Al-Awar, Rima, Katona, Bryson W., Shilatifard, Ali, Huang, Jing, Hua, Xianxin, Arrowsmith, Cheryl H., Berger, Shelley L.
Publicado no Nature (2015)

Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay

Por Hammoud, Lamis, Adams, Jessica R., Loch, Amanda J., Marcellus, Richard C., Uehling, David E., Aman, Ahmed, Fladd, Christopher, McKee, Trevor D., Jo, Christine E.B., Al-Awar, Rima, Egan, Sean E., Rossant, Janet
Publicado no Stem Cell Reports (2016)

COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS AND NOVEL TARGETS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS

Por Kaplan, David, Grinshtein, Natalie, Rioseco, Constanza, Luchman, Artee, Datti, Alessandro, Aman, Ahmed, Uehling, David, Prakesch, Michael, Wrana, Jeff, Cairncross, Greg, Shen, Yaoqing, Jones, Steve, Marra, Marco, Senger, Donna, Robbins, Steve, Al-Awar, Rima, Moran, Mike, Weiss, Samuel
Publicado em 2014

Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport

Por Zhang, Qiangmin, Xiao, Kunhong, Paredes, José M., Mamonova, Tatyana, Sneddon, W. Bruce, Liu, Hongda, Wang, Dawei, Li, Sheng, McGarvey, Jennifer C., Uehling, David, Al-awar, Rima, Joseph, Babu, Jean-Alphonse, Frederic, Orte, Angel, Friedman, Peter A.
Publicado no J Biol Chem (2019)

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction

Por Bolshan, Yuri, Getlik, Matthäus, Kuznetsova, Ekaterina, Wasney, Gregory A., Hajian, Taraneh, Poda, Gennadiy, Nguyen, Kong T., Wu, Hong, Dombrovski, Ludmila, Dong, Aiping, Senisterra, Guillermo, Schapira, Matthieu, Arrowsmith, Cheryl H., Brown, Peter J., Al-awar, Rima, Vedadi, Masoud, Smil, David
Publicado em 2013

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

Por Haftchenary, Sina, Luchman, H. Artee, Jouk, Andriana O., Veloso, Anthony J., Page, Brent D. G., Cheng, Xin Ran, Dawson, Sean S., Grinshtein, Natalie, Shahani, Vijay M., Kerman, Kagan, Kaplan, David R., Griffin, Carly, Aman, Ahmed M., Al-awar, Rima, Weiss, Samuel, Gunning, Patrick T.
Publicado em 2013

Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells

Por Grinshtein, Natalie, Rioseco, Constanza C., Marcellus, Richard, Uehling, David, Aman, Ahmed, Lun, Xueqing, Muto, Osamu, Podmore, Lauren, Lever, Jake, Shen, Yaoqing, Blough, Michael D., Cairncross, Greg J., Robbins, Stephen M., Jones, Steven J., Marra, Marco A., Al-Awar, Rima, Senger, Donna L., Kaplan, David R.
Publicado no Oncotarget (2016)

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

Por Senisterra, Guillermo, Wu, Hong, Allali-Hassani, Abdellah, Wasney, Gregory A., Barsyte-Lovejoy, Dalia, Dombrovski, Ludmila, Dong, Aiping, Nguyen, Kong T., Smil, David, Bolshan, Yuri, Hajian, Taraneh, He, Hao, Seitova, Alma, Chau, Irene, Li, Fengling, Poda, Gennadiy, Couture, Jean-François, Brown, Peter J., Al-Awar, Rima, Schapira, Matthieu, Arrowsmith, Cheryl H., Vedadi, Masoud
Publicado em 2012