An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies

Por Goard, Carolyn A, Schimmer, Aaron D
Publicado em 2013

Crystal Structure of the Human Ubiquitin-activating Enzyme 5 (UBA5) Bound to ATP: MECHANISTIC INSIGHTS INTO A MINIMALISTIC E1 ENZYME

Por Bacik, John-Paul, Walker, John R., Ali, Mohsin, Schimmer, Aaron D., Dhe-Paganon, Sirano
Publicado em 2010

New sources of drugs for hematologic malignancies

Por Sukhai, Mahadeo A., Spagnuolo, Paul A., Weir, Scott, Kasper, James, Patton, Lavonne, Schimmer, Aaron D.
Publicado em 2011

New model systems provide insights into Myc-induced transformation

Por Wasylishen, Amanda R, Stojanova, Angelina, Oliveri, Stefanie, Rust, Andrew C, Schimmer, Aaron D, Penn, Linda Z
Publicado em 2011

A Novel Formulation of Tigecycline Has Enhanced Stability and Sustained Antibacterial and Antileukemic Activity

Por Jitkova, Yulia, Gronda, Marcela, Hurren, Rose, Wang, Xiaoming, Goard, Carolyn A., Jhas, Bozhena, Schimmer, Aaron D.
Publicado em 2014

The Natural Pesticide Dihydrorotenone Induces Human Plasma Cell Apoptosis by Triggering Endoplasmic Reticulum Stress and Activating p38 Signaling Pathway

Por Zhang, Jieyu, Tang, Juan, Cao, Biyin, Zhang, Zubin, Li, Jie, Schimmer, Aaron D., He, Sudan, Mao, Xinliang
Publicado em 2013

Health care crisis in Gaza

Por Schimmer, Aaron D., Malkin, David, Zackenhaus, Eldad, Kagal, Allan, Klip, Amira, Rotin, Daniela, Minden, Mark D., Teitel, Jerome
Publicado em 2009

Targeting p53 via JNK Pathway: A Novel Role of RITA for Apoptotic Signaling in Multiple Myeloma

Por Saha, Manujendra N., Jiang, Hua, Yang, Yijun, Zhu, Xiaoyun, Wang, Xiaoming, Schimmer, Aaron D., Qiu, Lugui, Chang, Hong
Publicado em 2012

Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to TRAIL-Induced Apoptosis

Por Mamaghani, Shadi, Simpson, Craig D., Cao, Pinjiang M., Cheung, May, Chow, Sue, Bandarchi, Bizhan, Schimmer, Aaron D., Hedley, David W.
Publicado em 2012

Inhibition of SREBP1 sensitizes cells to death ligands

Por Eberhard, Yanina, Gronda, Marcela, Hurren, Rose, Datti, Alessandro, MacLean, Neil, Ketela, Troy, Moffat, Jason, Wrana, Jeffrey L., Schimmer, Aaron D.
Publicado em 2011

A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3- or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia

Por Schimmer, Aaron D., Raza, Azra, Carter, Thomas H., Claxton, David, Erba, Harry, DeAngelo, Daniel J., Tallman, Martin S., Goard, Carolyn, Borthakur, Gautam
Publicado em 2014

RB1 Status in Triple Negative Breast Cancer Cells Dictates Response to Radiation Treatment and Selective Therapeutic Drugs

Por Robinson, Tyler J. W., Liu, Jeff C., Vizeacoumar, Frederick, Sun, Thomas, Maclean, Neil, Egan, Sean E., Schimmer, Aaron D., Datti, Alessandro, Zacksenhaus, Eldad
Publicado em 2013

Identification of a Nonphosphorylated, Cell Permeable, Small Molecule Ligand for the Stat3 SH2 Domain

Por Page, Brent D. G., Fletcher, Steven, Yue, Peibin, Li, Zhihua, Zhang, Xiaolei, Sharmeen, Sumaiya, Trudel, Suzanne, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Publicado no Bioorg Med Chem Lett (2011)

A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia

Por Jeyaraju, Danny V., Hurren, Rose, Wang, Xiaoming, MacLean, Neil, Gronda, Marcela, Shamas-Din, Aisha, Minden, Mark D., Giaever, Guri, Schimmer, Aaron D.
Publicado no Oncotarget (2016)

Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein–protein interactions

Por Drewry, Joel A., Fletcher, Steven, Yue, Peibin, Marushchak, Denys, Zhao, Wei, Sharmeen, Sumaiya, Zhang, Xiaolei, Schimmer, Aaron D., Gradinaru, Claudiu, Turkson, James, Gunning, Patrick T.
Publicado em 2009

Increased pressure alters plasma membrane dynamics and renders acute myeloid leukemia cells resistant to daunorubicin

Por Nirmalanandhan, Victor Sanjit, Hurren, Rose, Cameron, William D., Gronda, Marcela, Shamas-Din, Aisha, You, Lidan, Minden, Mark D., Rocheleau, Jonathan V., Schimmer, Aaron D
Publicado no Haematologica (2015)

Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo

Por Tiedemann, Rodger E., Schmidt, Jessica, Keats, Jonathan J., Shi, Chang-Xin, Zhu, Yuan Xiao, Palmer, Stephen E., Mao, Xinliang, Schimmer, Aaron D., Stewart, A. Keith
Publicado em 2009

Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities

Por Fletcher, Steven, Singh, Jagdeep, Zhang, Xiaolei, Yue, Peibin, Page, Brent D. G., Sharmeen, Sumaiya, Shahani, Vijay M., Zhao, Wei, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Publicado em 2009

Identification of NAE Inhibitors Exhibiting Potent Activity in Leukemia Cells: Exploring the Structural Determinants of NAE Specificity

Por Lukkarila, Julie L., da Silva, Sara R., Ali, Mohsin, Shahani, Vijay M., Xu, G. Wei, Berman, Judd, Roughton, Andrew, Dhe-Paganon, Sirano, Schimmer, Aaron D., Gunning, Patrick T.
Publicado em 2011

Design, Synthesis and in vitro Characterization of Novel Hybrid Peptidomimetic Inhibitors of STAT3 Protein

Por Shahani, Vijay M., Yue, Peibin, Fletcher, Steven, Sharmeen, Sumaiya, Sukhai, Mahadeo A., Luu, Diana P., Zhang, Xiaolei, Sun, Hong, Zhao, Wei, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Publicado em 2010