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Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein–protein interactions
We report the first application of coordination complexes as functional proteomimetics of the Src homology 2 (SH2) phosphopeptide-binding domain. As a proof-of-concept, functionalized bis-dipicolylamine (BDPA) copper(ii) complexes are shown to disrupt oncogenic Stat3–Stat3 protein complexes and elic...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910512/ https://ncbi.nlm.nih.gov/pubmed/20107641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b919608k |
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