Identification of a Nonphosphorylated, Cell Permeable, Small Molecule Ligand for the Stat3 SH2 Domain

Signal transducer and activator of transcription 3 (Stat3) protein is a cytosolic transcription factor that is aberrantly activated in numerous human cancers. Inhibitors of activated Stat3–Stat3 protein complexes have been shown to hold therapeutic promise for the treatment of human cancers harborin...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Page, Brent D. G., Fletcher, Steven, Yue, Peibin, Li, Zhihua, Zhang, Xiaolei, Sharmeen, Sumaiya, Trudel, Suzanne, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530782/
https://ncbi.nlm.nih.gov/pubmed/21788134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.06.056
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