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A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes

The molecular modeling of the phosphotyrosine (pTyr)-SH2 domain interaction in the Stat3:Stat3 dimerization, combined with in silico structural analysis of the Stat3 dimerization disruptor, S3I-201, has furnished a diverse set of analogs. We present evidence from in vitro biochemical and biophysical...

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書誌詳細
主要な著者: Zhang, Xiaolei, Yue, Peibin, Fletcher, Steven, Zhao, Wei, Gunning, Patrick T., Turkson, James
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188443/
https://ncbi.nlm.nih.gov/pubmed/20067773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.01.001
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