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Antagonism of the Stat3–Stat3 Protein Dimer with Salicylic Acid Based Small Molecules
More than 50 new inhibitors of the oncogenic Stat3 protein were identified through a structure–activity relationship (SAR) study based on the previously identified inhibitor S3I-201 (IC(50) = 86 µm, K(i) > 300 µm). A key structural feature of these inhibitors is a salicylic acid moiety, which, by...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2011
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3192013/ https://ncbi.nlm.nih.gov/pubmed/21618433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100194 |
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