Targeting protein–protein interactions by rational design: mimicry of protein surfaces

Por Fletcher, Steven, Hamilton, Andrew D
Publicado em 2006

Small-Molecule Inhibitors of the Myc Oncoprotein

Por Fletcher, Steven, Prochownik, Edward V.
Publicado em 2014

Multi-Facial, Non-Peptidic α-Helix Mimetics

Por Lanning, Maryanna E., Fletcher, Steven
Publicado no Biology (Basel) (2015)

Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein

Por Fletcher, Steven, Turkson, James, Gunning, Patrick T.
Publicado em 2008

A quantitative, surface plasmon resonance-based approach to evaluating DNA binding by the c-Myc oncoprotein and its disruption by small molecule inhibitors

Por Wang, Huabo, Ramakrishnan, Anand, Fletcher, Steven, Prochownik, Edward V.
Publicado no J Biol Methods (2015)

A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes

Por Zhang, Xiaolei, Yue, Peibin, Fletcher, Steven, Zhao, Wei, Gunning, Patrick T., Turkson, James
Publicado em 2010

BCL-x(L)/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells

Por Perri, Mariarita, Yap, Jeremy L., Cione, Erika, Fletcher, Steven, Kane, Maureen A.
Publicado no Exp Cell Res (2014)

Small Molecule Inhibitors of the ERK Signalling Pathway: Towards Novel Anti-cancer Therapeutics

Por Yap, Jeremy L., Worlikar, Shilpa, MacKerell, Alexander D., Shapiro, Paul, Fletcher, Steven
Publicado em 2011

Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion

Por Wang, Huabo, Sharma, Lokendra, Lu, Jie, Finch, Paul, Fletcher, Steven, Prochownik, Edward V.
Publicado no Oncotarget (2015)

Ethyl 2,5-di-tert-butyl-5-eth­oxy-4-oxo-4,5-di­hydro-1H-pyrrole-3-carboxyl­ate

Por Rosen, Gerald M., Muralidharan, Sukumaran, Zavalij, Peter Y., Fletcher, Steven, Kao, Joseph P. Y.
Publicado em 2013

Baeyer-Villiger Rearrangement of a Substituted Pyrrole by Oxone

Por Kao, Joseph P. Y., Muralidharan, Sukumaran, Zavalij, Peter Y., Fletcher, Steven, Xue, Fengtian, Rosen, Gerald M.
Publicado em 2014

The effect of geniglossal advancement on airway flow using a computational flow dynamics model

Por Fletcher, Aaron, Choi, Jiwoong, Awadalla, Maged, Potash, Andrea E., Wallen, Tanner J., Fletcher, Steven, Chang, Eugene H.
Publicado em 2013

Discovery of Methyl 4′-Methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate, an Improved Small-Molecule Inhibitor of c-Myc–Max Dimerization

Por Chauhan, Jay, Wang, Huabo, Yap, Jeremy L., Sabato, Philip E., Hu, Angela, Prochownik, Edward V., Fletcher, Steven
Publicado em 2014

Surface Binding Inhibitors of the SCF–KIT Protein–Protein Interaction

Por Margulies, David, Opatowsky, Yarden, Fletcher, Steven, Saraogi, Ishu, Tsou, Lun K., Saha, Sourav, Lax, Irit, Schlessinger, Joseph, Hamilton, Andrew D.
Publicado em 2009

Pharmacophore identification of c-Myc inhibitor 10074-G5

Por Yap, Jeremy L., Wang, Huabo, Hu, Angela, Chauhan, Jay, Jung, Kwan-Young, Gharavi, Robert B., Prochownik, Edward V., Fletcher, Steven
Publicado em 2012

Structural Re-Engineering of the α-Helix Mimetic JY-1-106 into Small-Molecules: Disruption of the Mcl-1–Bak-BH3 Protein–Protein Interaction with 2,6-Di-Substituted Nicotinates

Por Drennen, Brandon, Scheenstra, Jacob A., Yap, Jeremy L., Chen, Lijia, Lanning, Maryanna E., Roth, B. M., Wilder, Paul T., Fletcher, Steven
Publicado no ChemMedChem (2016)

Structure–activity exploration of a small-molecule Lipid II inhibitor

Por Fletcher, Steven, Yu, Wenbo, Huang, Jing, Kwasny, Steven M, Chauhan, Jay, Opperman, Timothy J, MacKerell, Alexander D, de Leeuw, Erik PH
Publicado no Drug Des Devel Ther (2015)

BRD4 Structure–Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536

Por Chen, Lijia, Yap, Jeremy L., Yoshioka, Makoto, Lanning, Maryanna E., Fountain, Rachel N., Raje, Mithun, Scheenstra, Jacob A., Strovel, Jeffrey W., Fletcher, Steven
Publicado no ACS Med Chem Lett (2015)

Identification of a Nonphosphorylated, Cell Permeable, Small Molecule Ligand for the Stat3 SH2 Domain

Por Page, Brent D. G., Fletcher, Steven, Yue, Peibin, Li, Zhihua, Zhang, Xiaolei, Sharmeen, Sumaiya, Trudel, Suzanne, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Publicado no Bioorg Med Chem Lett (2011)

Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein–protein interactions

Por Drewry, Joel A., Fletcher, Steven, Yue, Peibin, Marushchak, Denys, Zhao, Wei, Sharmeen, Sumaiya, Zhang, Xiaolei, Schimmer, Aaron D., Gradinaru, Claudiu, Turkson, James, Gunning, Patrick T.
Publicado em 2009