A quantitative, surface plasmon resonance-based approach to evaluating DNA binding by the c-Myc oncoprotein and its disruption by small molecule inhibitors

Por Wang, Huabo, Ramakrishnan, Anand, Fletcher, Steven, Prochownik, Edward V.
Publicado no J Biol Methods (2015)

Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion

Por Wang, Huabo, Sharma, Lokendra, Lu, Jie, Finch, Paul, Fletcher, Steven, Prochownik, Edward V.
Publicado no Oncotarget (2015)

Discovery of Methyl 4′-Methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate, an Improved Small-Molecule Inhibitor of c-Myc–Max Dimerization

Por Chauhan, Jay, Wang, Huabo, Yap, Jeremy L., Sabato, Philip E., Hu, Angela, Prochownik, Edward V., Fletcher, Steven
Publicado em 2014

Discovery of Novel Myc-Max Heterodimer Disruptors with a 3-Dimensional Pharmacophore Model

Por Mustata, Gabriela, Follis, Ariele Viacava, Hammoudeh, Dalia I., Metallo, Steven J., Wang, Huabo, Prochownik, Edward V., Lazo, John S., Bahar, Ivet
Publicado em 2009

Pharmacophore identification of c-Myc inhibitor 10074-G5

Por Yap, Jeremy L., Wang, Huabo, Hu, Angela, Chauhan, Jay, Jung, Kwan-Young, Gharavi, Robert B., Prochownik, Edward V., Fletcher, Steven
Publicado em 2012

Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5

Por Wang, Huabo, Chauhan, Jay, Hu, Angela, Pendleton, Kelsey, Yap, Jeremy L., Sabato, Philip E., Jones, Jace W., Perri, Mariarita, Yu, Jianshi, Cione, Erika, Kane, Maureen A., Fletcher, Steven, Prochownik, Edward V.
Publicado em 2013

Perturbation of the c-Myc–Max Protein–Protein Interaction via Synthetic α-Helix Mimetics

Por Jung, Kwan-Young, Wang, Huabo, Teriete, Peter, Yap, Jeremy L., Chen, Lijia, Lanning, Maryanna E., Hu, Angela, Lambert, Lester J., Holien, Toril, Sundan, Anders, Cosford, Nicholas, Prochownik, Edward V., Fletcher, Steven
Publicado no J Med Chem (2015)

c-Myc and AMPK Control Cellular Energy Levels by Cooperatively Regulating Mitochondrial Structure and Function

Por Edmunds, Lia R., Sharma, Lokendra, Wang, Huabo, Kang, Audry, d’Souza, Sonia, Lu, Jie, McLaughlin, Michael, Dolezal, James M., Gao, Xiaoli, Weintraub, Susan T., Ding, Ying, Zeng, Xuemei, Yates, Nathan, Prochownik, Edward V.
Publicado no PLoS One (2015)

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids

Por Wang, Huabo, Teriete, Peter, Hu, Angela, Raveendra-Panickar, Dhanya, Pendelton, Kelsey, Lazo, John S., Eiseman, Julie, Holien, Toril, Misund, Kristine, Oliynyk, Ganna, Arsenian-Henriksson, Marie, Cosford, Nicholas D. P, Sundan, Anders, Prochownik, Edward V.
Publicado no Oncotarget (2015)

Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma

Por Wang, Huabo, Lu, Jie, Edmunds, Lia R., Kulkarni, Sucheta, Dolezal, James, Tao, Junyan, Ranganathan, Sarangarajan, Jackson, Laura, Fromherz, Marc, Beer-Stolz, Donna, Uppala, Radha, Bharathi, Sivakama, Monga, Satdarshan P., Goetzman, Eric S., Prochownik, Edward V.
Publicado no J Biol Chem (2016)