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Discovery of Novel Myc-Max Heterodimer Disruptors with a 3-Dimensional Pharmacophore Model
A 3-dimensional pharmacophore model was generated utilizing a set of known inhibitors of c-Myc-Max heterodimer formation. The model successfully identified a set of structurally diverse compounds with potential inhibitory activity against c-Myc. Nine compounds were tested in vitro, and four displaye...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765518/ https://ncbi.nlm.nih.gov/pubmed/19215087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801278g |
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