Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

OBJECTIVES: c-Myc is commonly activated in many human tumors and is functionally important in cellular proliferation, differentiation, apoptosis and cell cycle progression. The activity of c-Myc requires noncovalent interaction with its client protein Max. In vitro studies indicate the thioxothiazol...

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Main Authors: Guo, Jianxia, Parise, Robert A., Joseph, Erin, Egorin, Merrill J., Lazo, John S., Prochownik, Edward V., Eiseman, Julie L.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752825/
https://ncbi.nlm.nih.gov/pubmed/18509642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-008-0774-y
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