In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization

The c-Myc oncoprotein is overexpressed in many tumors and is essential for maintaining the proliferation of transformed cells. To function as a transcription factor, c-Myc must dimerize with Max via the basic helix-loop-helix leucine zipper protein (bHLH-ZIP) domains in each protein. The small molec...

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Main Authors: Clausen, Dana M., Guo, Jianxia, Parise, Robert A., Beumer, Jan H., Egorin, Merrill J., Lazo, John S., Prochownik, Edward V., Eiseman, Julie L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Chemotherapy, Antibiotics, and Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993546/
https://ncbi.nlm.nih.gov/pubmed/20801893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.170555
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