In vitro Cytotoxicity, Pharmacokinetics, Tissue Distribution, and Metabolism of Small-Molecule Protein Kinase D Inhibitors, kb-NB142-70 and kb-NB165-09, in Mice bearing Human Cancer Xenografts

PURPOSE: Protein kinase D (PKD) mediates diverse biological responses including cell growth and survival. Therefore, PKD inhibitors may have therapeutic potential. We evaluated the in vitro cytotoxicity of two PKD inhibitors, kb-NB142-70 and its methoxy analog, kb-NB165-09, and examined their in viv...

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Detalhes bibliográficos
Main Authors: Guo, Jianxia, Clausen, Dana M., Beumer, Jan H., Parise, Robert A., Egorin, Merrill J., Bravo-Altamirano, Karla, Wipf, Peter, Sharlow, Elizabeth R., Wang, Qiming Jane, Eiseman, Julie L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557573/
https://ncbi.nlm.nih.gov/pubmed/23108699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-2010-z
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