Liquid chromatography-mass spectrometric assay for the quantitation in human plasma of ABT-888, an orally available, small molecule inhibitor of poly(ADP-ribose) polymerase

ABT-888, a PARP-inhibitor in clinical trials, potentiates DNA-damaging agents. We developed and validated, according to FDA guidelines, an LC-MS assay for sensitive, accurate and precise quantitation of ABT-888 and its metabolite M8 in 0.2 ml human plasma. After ethyl acetate extraction, separation...

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Hlavní autoři: Parise, Robert A., Shawaqfeh, Mohammad, Egorin, Merrill J., Beumer, Jan H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634284/
https://ncbi.nlm.nih.gov/pubmed/18692448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2008.07.032
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