Radiosensitization of Pancreatic Cancer Cells In Vitro and In Vivo through Poly (ADP-ribose) Polymerase Inhibition with ABT-888

OBJECTIVES: To determine whether poly (ADP-ribose) polymerase-1/2 (PARP-1/2) inhibition enhances radiation-induced cytotoxicity of pancreatic adenocarcinoma in vitro and in vivo, and the mechanism by which this occurs. METHODS: Pancreatic carcinoma cells were treated with ABT-888, radiation, or both...

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Main Authors: Tuli, Richard, Surmak, Andrew J., Reyes, Juvenal, Armour, Michael, Hacker-Prietz, Amy, Wong, John, DeWeese, Theodore L., Herman, Joseph M.
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145354/
https://ncbi.nlm.nih.gov/pubmed/24836647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2014.04.003
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