Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma

BACKGROUND: The cytotoxicity of radiotherapy and chemotherapy can be enhanced by modulating DNA repair. PARP is a family of enzymes required for an efficient base-excision repair of DNA single-strand breaks and inhibition of PARP can prevent the repair of these lesions. The current study investigate...

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Autori principali: Barazzuol, Lara, Jena, Raj, Burnet, Neil G, Meira, Lisiane B, Jeynes, Jonathan C G, Kirkby, Karen J, Kirkby, Norman F
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622565/
https://ncbi.nlm.nih.gov/pubmed/23510353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-8-65
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