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Liquid chromatography-mass spectrometric assay for the quantitation in human plasma of ABT-888, an orally available, small molecule inhibitor of poly(ADP-ribose) polymerase
ABT-888, a PARP-inhibitor in clinical trials, potentiates DNA-damaging agents. We developed and validated, according to FDA guidelines, an LC-MS assay for sensitive, accurate and precise quantitation of ABT-888 and its metabolite M8 in 0.2 ml human plasma. After ethyl acetate extraction, separation...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2634284/ https://ncbi.nlm.nih.gov/pubmed/18692448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2008.07.032 |
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