Formation of active products of benzaldehyde dimethane sulfonate (NSC 281612, DMS612) in human blood and plasma and their activity against renal cell carcinoma lines

Benzaldehyde dimethane sulfonate (BEN, DMS612, NSC281612) is an alkylating agent with activity against renal cell carcinoma and is being evaluated clinically. To support clinical trials, we developed an LC–MS/MS assay to detect and quantitate BEN and its metabolites/decomposition products. We tested...

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Bibliografiske detaljer
Main Authors: Parise, Robert A., Anyang, Bean N., Eiseman, Julie L., Egorin, Merrill J., Covey, Joseph M., Beumer, Jan H.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536923/
https://ncbi.nlm.nih.gov/pubmed/23053264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1980-1
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