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Formation of active products of benzaldehyde dimethane sulfonate (NSC 281612, DMS612) in human blood and plasma and their activity against renal cell carcinoma lines
Benzaldehyde dimethane sulfonate (BEN, DMS612, NSC281612) is an alkylating agent with activity against renal cell carcinoma and is being evaluated clinically. To support clinical trials, we developed an LC–MS/MS assay to detect and quantitate BEN and its metabolites/decomposition products. We tested...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3536923/ https://ncbi.nlm.nih.gov/pubmed/23053264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1980-1 |
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