Formation of active products of benzaldehyde dimethane sulfonate (NSC 281612, DMS612) in human blood and plasma and their activity against renal cell carcinoma lines

Por Parise, Robert A., Anyang, Bean N., Eiseman, Julie L., Egorin, Merrill J., Covey, Joseph M., Beumer, Jan H.
Publicado em 2012

Comparative Metabolism of Batracylin (NSC 320846) and N-acetylbatracylin (NSC 611001) Using Human, Dog, and Rat Preparations In Vitro

Por Covey, Joseph M, Reid, Joel M, Buhrow, Sarah A, Kuffel, Mary, Walden, Chad, Behrsing, Holger, Ames, Matthew M
Publicado no J Drug Metab Toxicol (2016)

Liquid chromatography-tandem mass spectrometric assay for the quantitation in human plasma of the novel indenoisoquinoline topoisomerase I inhibitors, NSC 743400 and NSC 725776

Por Holleran, Julianne L., Parise, Robert A., Yellow-Duke, Archibong E., Egorin, Merrill J., Eiseman, Julie L., Covey, Joseph M., Beumer, Jan H.
Publicado em 2010

LC–MS/MS quantification of a neuropeptide fragment kisspeptin-10 (NSC 741805) and characterization of its decomposition product and pharmacokinetics in rats

Por Liu, Zhongfa, Ren, Chen, Jones, William, Chen, Ping, Seminara, Stephanie B., Chan, Yee-Ming, Smith, Nicola F., Covey, Joseph M., Wang, Jeffrey, Chan, Kenneth K.
Publicado em 2013

Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma

Por Parise, Robert A., Beumer, Jan H., Kangani, Cyrous O., Holleran, Julianne L., Eiseman, Julie L., Smith, Nicola F., Covey, Joseph M., Perrine, Susan P., Egorin, Merrill J.
Publicado em 2007

Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice

Por Beumer, Jan H., Eiseman, Julie L., Parise, Robert A., Florian, Jeffry A., Joseph, Erin, D’Argenio, David Z., Parker, Robert S., Kay, Brittany, Covey, Joseph M., Egorin, Merrill J.
Publicado em 2007

Oral and intravenous pharmacokinetics of 5-fluoro-2’-deoxycytidine and THU in cynomolgus monkeys and humans

Por Holleran, Julianne L., Beumer, Jan H., McCormick, David L., Johnson, William D., Newman, Edward M., Doroshow, James H., Kummar, Shivaani, Covey, Joseph M., Davis, Myrtle, Eiseman, Julie L.
Publicado no Cancer Chemother Pharmacol (2015)

Plasma pharmacokinetics of the indenoisoquinoline topoisomerase I inhibitor, NSC 743400, in rats and dogs

Por Muzzio, Miguel, Hu, Shu-Chieh, Holleran, Julianne L., Parise, Robert A., Eiseman, Julie L., Yellow-Duke, Archibong E., Covey, Joseph M., Glaze, Elizabeth R., Engelke, Kory, Egorin, Merrill J., McCormicka, David L., Beumer, Jan H.
Publicado no Cancer Chemother Pharmacol (2015)

Preclinical Pharmacokinetics Study of R- and S-Enantiomers of the Histone Deacetylase Inhibitor, AR-42 (NSC 731438), in Rodents

Por Cheng, Hao, Xie, Zhiliang, Jones, William P., Wei, Xiaohui Tracey, Liu, Zhongfa, Wang, Dasheng, Kulp, Samuel K., Wang, Jiang, Coss, Christopher C., Chen, Ching-Shih, Marcucci, Guido, Garzon, Ramiro, Covey, Joseph M., Phelps, Mitch A., Chan, Kenneth K.
Publicado no AAPS J (2016)

Characterization of Silvestrol Pharmacokinetics in Mice Using Liquid Chromatography–Tandem Mass Spectrometry

Por Saradhi, U. V. R. Vijaya, Gupta, Sneha V., Chiu, Ming, Wang, Jiang, Ling, Yonghua, Liu, Zhongfa, Newman, David J., Covey, Joseph M., Kinghorn, A. Douglas, Marcucci, Guido, Lucas, David M., Grever, Michael R., Phelps, Mitch A., Chan, Kenneth K.
Publicado em 2011

Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice

Por Beumer, Jan H., Eiseman, Julie L., Gilbert, Judith A., Holleran, Julianne L., Yellow-Duke, Archibong E., Clausen, Dana M., D’Argenio, David Z., Ames, Matthew M., Hershberger, Pamela A., Parise, Robert A., Bai, Lihua, Covey, Joseph M., Egorin, Merrill J.
Publicado em 2010