Molecular Pathways: Targeting PARP in Cancer Treatment

Por Do, Khanh, Chen, Alice P.
Publicado em 2012

New treatment option for ovarian cancer: PARP inhibitors

Por Meehan, Robert S., Chen, Alice P.
Publicado no Gynecol Oncol Res Pract (2016)

PARP Inhibitors in Reproductive System Cancers: Current Use and Developments

Por O’Sullivan Coyne, Geraldine, Chen, Alice P., Meehan, Robert, Doroshow, James H.
Publicado no Drugs (2017)

Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors

Por Do, Khanh, Wilsker, Deborah, Ji, Jiuping, Zlott, Jennifer, Freshwater, Tomoko, Kinders, Robert J., Collins, Jerry, Chen, Alice P., Doroshow, James H., Kummar, Shivaani
Publicado no J Clin Oncol (2015)

Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent

Por Nguyen, Diana, Zajac-Kaye, Maria, Rubinstein, Larry, Voeller, Donna, Tomaszewski, Joseph E, Kummar, Shivaani, Chen, Alice P, Pommier, Yves, Doroshow, James H, Yang, Sherry X
Publicado em 2011

Application of Molecular Profiling in Clinical Trials for Advanced Metastatic Cancers

Por Kummar, Shivaani, Williams, P. Mickey, Lih, Chih-Jian, Polley, Eric C., Chen, Alice P., Rubinstein, Larry V., Zhao, Yingdong, Simon, Richard M., Conley, Barbara A., Doroshow, James H.
Publicado no J Natl Cancer Inst (2015)

Phase I, Pharmacokinetic and Pharmacodynamic Study of SJG-136, a Novel DNA Sequence Selective Minor Groove Cross-Linking Agent, in advanced solid tumors

Por Puzanov, Igor, Lee, Wooin, Chen, Alice P., Calcutt, M. Wade, Hachey, David. L., Vermeulen, Wendy L., Spanswick, Victoria J., Liao, Chih-Yi, Hartley, John A., Berlin, Jordan D., Rothenberg, Mace L.
Publicado em 2011

Randomized Phase II trial of Cyclophosphamide and the Oral Poly (ADP-ribose) Polymerase Inhibitor Veliparib in Patients with Recurrent, Advanced Triple-Negative Breast Cancer

Por Kummar, Shivaani, Wade, James L., Oza, Amit M., Sullivan, Daniel, Chen, Alice P., Gandara, David R., Ji, Jiuping, Kinders, Robert J., Wang, Lihua, Allen, Deborah, Coyne, Geraldine O’Sullivan, Steinberg, Seth M., Doroshow, James H.
Publicado no Invest New Drugs (2016)

GeneMed: An Informatics Hub for the Coordination of Next-Generation Sequencing Studies that Support Precision Oncology Clinical Trials

Por Zhao, Yingdong, Polley, Eric C, Li, Ming-Chung, Lih, Chih-Jian, Palmisano, Alida, Sims, David J, Rubinstein, Lawrence V, Conley, Barbara A, Chen, Alice P, Williams, P Mickey, Kummar, Shivaani, Doroshow, James H, Simon, Richard M
Publicado no Cancer Inform (2015)

Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay

Por Ji, Jiuping, Zhang, Yiping, Redon, Christophe E., Reinhold, William C., Chen, Alice P., Fogli, Laura K., Holbeck, Susan L., Parchment, Ralph E., Hollingshead, Melinda, Tomaszewski, Joseph E., Dudon, Quentin, Pommier, Yves, Doroshow, James H., Bonner, William M.
Publicado no PLoS One (2017)

Phase I safety, pharmacokinetic and pharmacodynamic study of the poly (ADP-ribose) polymerase (PARP) inhibitor veliparib (ABT-888) in combination with irinotecan in patients with a...

Por LoRusso, Patricia M., Li, Jing, Burger, Angelika, Heilbrun, Lance K., Sausville, Edward A., Boerner, Scott A., Smith, Daryn, Pilat, Mary Jo, Zhang, Jie, Tolaney, Sara M., Cleary, James M., Chen, Alice P., Rubinstein, Lawrence, Boerner, Julie L., Bowditch, Adam, Cai, Dongpo, Bell, Tracy, Wolanski, Andrew, Marrero, Allison M., Zhang, Yiping, Ji, Jiuping, Ferry-Galow, Katherine, Kinders, Robert J., Parchment, Ralph E., Shapiro, Geoffrey I.
Publicado no Clin Cancer Res (2016)

Randomized trial of oral cyclophosphamide and veliparib in high-grade serous ovarian, primary peritoneal, or fallopian tube cancers, or BRCA-mutant ovarian cancer

Por Kummar, Shivaani, Oza, Amit M., Fleming, Gini F., Sullivan, Daniel M., Gandara, David R., Naughton, Michael J., Villalona-Calero, Miguel A., Morgan, Robert J., Szabo, Peter M., Youn, Ahrim, Chen, Alice P., Ji, Jiuping, Allen, Deborah E., Lih, Chih-Jian, Mehaffey, Michele G., Walsh, William D., McGregor, Paul M., Steinberg, Seth M., Williams, Paul M., Kinders, Robert J., Conley, Barbara A., Simon, Richard M., Doroshow, James H.
Publicado no Clin Cancer Res (2015)