Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts

Autor Kinders, Robert J., Hollingshead, Melinda, Khin, Sonny, Rubinstein, Larry, Tomaszewski, Joseph E., Doroshow, James H., Parchment, Ralph E.
Vydáno 2008

Advances in using PARP inhibitors to treat cancer

Autor Kummar, Shivaani, Chen, Alice, Parchment, Ralph E, Kinders, Robert J, Ji, Jay, Tomaszewski, Joseph E, Doroshow, James H
Vydáno 2012

Modeling Pharmacodynamic Response to the Poly(ADP-Ribose) Polymerase Inhibitor ABT-888 in Human Peripheral Blood Mononuclear Cells

Autor Ji, Jiuping, Kinders, Robert J., Zhang, Yiping, Rubinstein, Larry, Kummar, Shivaani, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Vydáno 2011

TET2 and DNMT3A mutations and exceptional response to 4′-thio-2′-deoxycytidine in human solid tumor models

Autor Yang, Sherry X., Hollingshead, Melinda, Rubinstein, Larry, Nguyen, Dat, Larenjeira, Angelo B. A., Kinders, Robert J., Difilippantonio, Michael, Doroshow, James H.
Vydáno v J Hematol Oncol (2021)

Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors

Autor Do, Khanh, Wilsker, Deborah, Ji, Jiuping, Zlott, Jennifer, Freshwater, Tomoko, Kinders, Robert J., Collins, Jerry, Chen, Alice P., Doroshow, James H., Kummar, Shivaani
Vydáno v J Clin Oncol (2015)

Validation of a Hypoxia-Inducible Factor-1α Specimen Collection Procedure and Quantitative ELISA in Solid Tumor Tissues

Autor Park, Sook Ryun, Kinders, Robert J., Khin, Sonny, Hollingshead, Melinda, Antony, Smitha, Parchment, Ralph E., Tomaszewski, Joseph E., Kummar, Shivaani, Doroshow, James H.
Vydáno v Anal Biochem (2014)

NANOG Modulates Stemness in Human Colorectal Cancer

Autor Zhang, Jingyu, Espinoza, Luis A., Kinders, Robert J., Lawrence, Scott M., Pfister, Thomas D., Zhou, Ming, Veenstra, Timothy D., Thorgeirsson, Snorri S., Jessup, J. Milburn
Vydáno 2012

Development of a quantitative pharmacodynamic assay for apoptosis in fixed tumor tissue and its application in distinguishing cytotoxic drug—induced DNA double strand breaks from D...

Autor Dull, Angie B., Wilsker, Deborah, Hollingshead, Melinda, Mazcko, Christina, Annunziata, Christina M., LeBlanc, Amy K., Doroshow, James H., Kinders, Robert J., Parchment, Ralph E.
Vydáno v Oncotarget (2018)

Topoisomerase I Levels in the NCI-60 Cancer Cell line Panel Determined by Validated ELISA and Microarray Analysis and Correlation with Indenoisoquinoline Sensitivity

Autor Pfister, Thomas D., Reinhold, William, Agama, Keli, Gupta, Shalu, Khin, Sonny A., Kinders, Robert J., Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H., Pommier, Yves
Vydáno 2009

Evaluation of pharmacodynamic responses to cancer therapeutic agents using DNA damage markers

Autor Wilsker, Deborah F., Barrett, Allison M., Dull, Angie B., Lawrence, Scott M., Hollingshead, Melinda, Chen, Alice P., Kummar, Shivaani, Parchment, Ralph E., Doroshow, James H., Kinders, Robert J.
Vydáno v Clin Cancer Res (2019)

Weekly EZN-2208 (PEGylated SN-38) in combination with bevacizumab in patients with refractory solid tumors

Autor Jeong, Woondong, Ryun Park, Sook, Rapisarda, Annamaria, Fer, Nicole, Kinders, Robert J., Chen, Alice, Melillo, Giovanni, Turkbey, Baris, Steinberg, Seth M., Choyke, Peter, Doroshow, James H., Kummar, Shivaani
Vydáno v Invest New Drugs (2013)

Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer

Autor Do, Khanh, Speranza, Giovanna, Bishop, Rachel, Khin, Sonny, Rubinstein, Larry, Kinders, Robert J., Datiles, Manuel, Eugeni, Michelle, Lam, Michael H., Doyle, L. Austin, Doroshow, James H., Kummar, Shivaani
Vydáno v Invest New Drugs (2015)

Development of a Validated Immunofluorescence Assay for γH2AX as a Pharmacodynamic Marker of Topoisomerase I Inhibitor Activity

Autor Kinders, Robert J., Hollingshead, Melinda, Lawrence, Scott, Ji, Jiuping, Tabb, Brian, Bonner, William M., Pommier, Yves, Rubinstein, Larry, Evrard, Yvonne A., Parchment, Ralph E., Tomaszewski, Joseph, Doroshow, James H.
Vydáno 2010

Monitoring Drug-Induced γH2AX as a Pharmacodynamic Biomarker in Individual Circulating Tumor Cells

Autor Wang, Lihua H., Pfister, Thomas D., Parchment, Ralph E., Kummar, Shivaani, Rubinstein, Larry, Evrard, Yvonne A., Gutierrez, Martin E., Murgo, Anthony J., Tomaszewski, Joseph E., Doroshow, James H., Kinders, Robert J.
Vydáno 2010

Increased anti-tumor activity of bevacizumab in combination with HIF-1 inhibition

Autor Rapisarda, Annamaria, Hollingshead, Melinda, Uranchimeg, Badarch, Bonomi, Carrie A., Borgel, Suzanne D., Carter, John P., Gehrs, Bradley, Raffeld, Mark, Kinders, Robert J., Parchment, Ralph, Anver, Miriam R., Shoemaker, Robert H., Melillo, Giovanni
Vydáno 2009

Antibody-independent capture of circulating tumor cells of non-epithelial origin with the ApoStream(®) system

Autor Balasubramanian, Priya, Kinders, Robert J., Kummar, Shivaani, Gupta, Vishal, Hasegawa, David, Menachery, Anoop, Lawrence, Scott M., Wang, Lihua, Ferry-Galow, Katherine, Davis, Darren, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Vydáno v PLoS One (2017)

Cediranib for Metastatic Alveolar Soft Part Sarcoma

Autor Kummar, Shivaani, Allen, Deborah, Monks, Anne, Polley, Eric C., Hose, Curtis D., Ivy, S. Percy, Turkbey, Ismail B., Lawrence, Scott, Kinders, Robert J., Choyke, Peter, Simon, Richard, Steinberg, Seth M., Doroshow, James H., Helman, Lee
Vydáno 2013

Characterization of Batracylin-Induced Renal and Bladder Toxicity in Rats

Autor Davis, Myrtle, Bunin, Deborah I., Samuelsson, Steven J., Altera, Kenneth P., Kinders, Robert J., Lawrence, Scott M, Ji, Jiuping, Ames, Matthew M., Buhrow, Sarah A., Walden, Chad, Reid, Joel M., Rausch, Linda L., Parman, Toufan
Vydáno v Toxicol Pathol (2014)

Randomized Phase II trial of Cyclophosphamide and the Oral Poly (ADP-ribose) Polymerase Inhibitor Veliparib in Patients with Recurrent, Advanced Triple-Negative Breast Cancer

Autor Kummar, Shivaani, Wade, James L., Oza, Amit M., Sullivan, Daniel, Chen, Alice P., Gandara, David R., Ji, Jiuping, Kinders, Robert J., Wang, Lihua, Allen, Deborah, Coyne, Geraldine O’Sullivan, Steinberg, Seth M., Doroshow, James H.
Vydáno v Invest New Drugs (2016)

Molecular Pharmacodynamics-Guided Scheduling of Biologically Effective Doses: A Drug Development Paradigm Applied to MET Tyrosine Kinase Inhibitors

Autor Srivastava, Apurva K., Hollingshead, Melinda G., Govindharajulu, Jeevan P., Covey, Joseph M., Liston, Dane, Simpson, Melanie A., Peggins, James O., Bottaro, Donald P., Wright, John J., Kinders, Robert J., Doroshow, James H., Parchment, Ralph E.
Vydáno v Mol Cancer Ther (2018)