Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts

Por Kinders, Robert J., Hollingshead, Melinda, Khin, Sonny, Rubinstein, Larry, Tomaszewski, Joseph E., Doroshow, James H., Parchment, Ralph E.
Publicado em 2008

Advances in using PARP inhibitors to treat cancer

Por Kummar, Shivaani, Chen, Alice, Parchment, Ralph E, Kinders, Robert J, Ji, Jay, Tomaszewski, Joseph E, Doroshow, James H
Publicado em 2012

Modeling Pharmacodynamic Response to the Poly(ADP-Ribose) Polymerase Inhibitor ABT-888 in Human Peripheral Blood Mononuclear Cells

Por Ji, Jiuping, Kinders, Robert J., Zhang, Yiping, Rubinstein, Larry, Kummar, Shivaani, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Publicado em 2011

Phase I Study of Single-Agent AZD1775 (MK-1775), a Wee1 Kinase Inhibitor, in Patients With Refractory Solid Tumors

Por Do, Khanh, Wilsker, Deborah, Ji, Jiuping, Zlott, Jennifer, Freshwater, Tomoko, Kinders, Robert J., Collins, Jerry, Chen, Alice P., Doroshow, James H., Kummar, Shivaani
Publicado no J Clin Oncol (2015)

Validation of a Hypoxia-Inducible Factor-1α Specimen Collection Procedure and Quantitative ELISA in Solid Tumor Tissues

Por Park, Sook Ryun, Kinders, Robert J., Khin, Sonny, Hollingshead, Melinda, Antony, Smitha, Parchment, Ralph E., Tomaszewski, Joseph E., Kummar, Shivaani, Doroshow, James H.
Publicado no Anal Biochem (2014)

NANOG Modulates Stemness in Human Colorectal Cancer

Por Zhang, Jingyu, Espinoza, Luis A., Kinders, Robert J., Lawrence, Scott M., Pfister, Thomas D., Zhou, Ming, Veenstra, Timothy D., Thorgeirsson, Snorri S., Jessup, J. Milburn
Publicado em 2012

Topoisomerase I Levels in the NCI-60 Cancer Cell line Panel Determined by Validated ELISA and Microarray Analysis and Correlation with Indenoisoquinoline Sensitivity

Por Pfister, Thomas D., Reinhold, William, Agama, Keli, Gupta, Shalu, Khin, Sonny A., Kinders, Robert J., Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H., Pommier, Yves
Publicado em 2009

Development of a Validated Immunofluorescence Assay for γH2AX as a Pharmacodynamic Marker of Topoisomerase I Inhibitor Activity

Por Kinders, Robert J., Hollingshead, Melinda, Lawrence, Scott, Ji, Jiuping, Tabb, Brian, Bonner, William M., Pommier, Yves, Rubinstein, Larry, Evrard, Yvonne A., Parchment, Ralph E., Tomaszewski, Joseph, Doroshow, James H.
Publicado em 2010

Monitoring Drug-Induced γH2AX as a Pharmacodynamic Biomarker in Individual Circulating Tumor Cells

Por Wang, Lihua H., Pfister, Thomas D., Parchment, Ralph E., Kummar, Shivaani, Rubinstein, Larry, Evrard, Yvonne A., Gutierrez, Martin E., Murgo, Anthony J., Tomaszewski, Joseph E., Doroshow, James H., Kinders, Robert J.
Publicado em 2010

Increased anti-tumor activity of bevacizumab in combination with HIF-1 inhibition

Por Rapisarda, Annamaria, Hollingshead, Melinda, Uranchimeg, Badarch, Bonomi, Carrie A., Borgel, Suzanne D., Carter, John P., Gehrs, Bradley, Raffeld, Mark, Kinders, Robert J., Parchment, Ralph, Anver, Miriam R., Shoemaker, Robert H., Melillo, Giovanni
Publicado em 2009

Antibody-independent capture of circulating tumor cells of non-epithelial origin with the ApoStream(®) system

Por Balasubramanian, Priya, Kinders, Robert J., Kummar, Shivaani, Gupta, Vishal, Hasegawa, David, Menachery, Anoop, Lawrence, Scott M., Wang, Lihua, Ferry-Galow, Katherine, Davis, Darren, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Publicado no PLoS One (2017)

Cediranib for Metastatic Alveolar Soft Part Sarcoma

Por Kummar, Shivaani, Allen, Deborah, Monks, Anne, Polley, Eric C., Hose, Curtis D., Ivy, S. Percy, Turkbey, Ismail B., Lawrence, Scott, Kinders, Robert J., Choyke, Peter, Simon, Richard, Steinberg, Seth M., Doroshow, James H., Helman, Lee
Publicado em 2013

Characterization of Batracylin-Induced Renal and Bladder Toxicity in Rats

Por Davis, Myrtle, Bunin, Deborah I., Samuelsson, Steven J., Altera, Kenneth P., Kinders, Robert J., Lawrence, Scott M, Ji, Jiuping, Ames, Matthew M., Buhrow, Sarah A., Walden, Chad, Reid, Joel M., Rausch, Linda L., Parman, Toufan
Publicado no Toxicol Pathol (2014)

Randomized Phase II trial of Cyclophosphamide and the Oral Poly (ADP-ribose) Polymerase Inhibitor Veliparib in Patients with Recurrent, Advanced Triple-Negative Breast Cancer

Por Kummar, Shivaani, Wade, James L., Oza, Amit M., Sullivan, Daniel, Chen, Alice P., Gandara, David R., Ji, Jiuping, Kinders, Robert J., Wang, Lihua, Allen, Deborah, Coyne, Geraldine O’Sullivan, Steinberg, Seth M., Doroshow, James H.
Publicado no Invest New Drugs (2016)

A multi-histology trial of fostamatinib in patients with advanced colorectal, non-small cell lung, head and neck, thyroid, and renal cell carcinomas, and pheochromocytomas

Por Park, Sook Ryun, Speranza, Giovanna, Piekarz, Richard, Wright, John J., Kinders, Robert J., Wang, Lihua, Pfister, Thomas D., Trepel, Jane B., Lee, Min-Jung, Alarcon, Sylvia, Steinberg, Seth M., Collins, Jerry, Doroshow, James H., Kummar, Shivaani
Publicado no Cancer Chemother Pharmacol (2013)

A Phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy in patients with advanced solid malignancies and peritoneal carci...

Por Reiss, Kim A., Herman, Joseph M., Zahurak, Marianna, Brade, Anthony, Dawson, Laura A., Scardina, Angela, Joffe, Caitlin, Petito, Emily, Hacker-Prietz, Amy, Kinders, Robert J., Wang, Lihua, Chen, Alice, Temkin, Sarah, Horiba, Naomi, Siu, Lillian L., Azad, Nilofer S.
Publicado no Clin Cancer Res (2014)

Development and Validation of an Immunoassay for Quantification of Topoisomerase I in Solid Tumor Tissues

Por Pfister, Thomas D., Hollingshead, Melinda, Kinders, Robert J., Zhang, Yiping, Evrard, Yvonne A., Ji, Jiuping, Khin, Sonny A., Borgel, Suzanne, Stotler, Howard, Carter, John, Divelbiss, Raymond, Kummar, Shivaani, Pommier, Yves, Parchment, Ralph E., Tomaszewski, Joseph E., Doroshow, James H.
Publicado em 2012

Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use

Por Srivastava, Apurva K., Jaganathan, Soumya, Stephen, Laurie, Hollingshead, Melinda G., Layhee, Adam, Damour, Eric, Govindharajulu, Jeevan Prasaad, Donohue, Jennifer, Esposito, Dominic, Mapes, James P., Kinders, Robert J., Takebe, Naoko, Tomaszewski, Joseph E., Kummar, Shivaani, Doroshow, James H., Parchment, Ralph E.
Publicado no Clin Cancer Res (2015)

Pharmacodynamic markers and clinical results from the Phase II Study of the SMAC-Mimetic Birinapant in Women with Relapsed Platinum-Resistant or Refractory Epithelial Ovarian Cance...

Por Noonan, Anne M., Bunch, Kristen P., Chen, Jin-Qiu, Herrmann, Michelle A., Lee, Jung-min, Kohn, Elise C., O’Sullivan, Ciara C., Jordan, Elizabeth, Houston, Nicole, Takebe, Naoko, Kinders, Robert J., Cao, Liang, Peer, Cody J., Figg, W. Douglas, Annunziata, Christina M.
Publicado no Cancer (2015)

A final report of a phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy (LDFWAR) in patients with advanced solid malign...

Por Reiss, Kim A., Herman, Joseph M., Armstrong, Deborah, Zahurak, Marianna, Fyles, Anthony, Brade, Anthony, Milosevic, Michael, Dawson, Laura A., Scardina, Angela, Fischer, Patricia, Hacker-Prietz, Amy, Kinders, Robert J., Wang, Lihua, Chen, Alice, Temkin, Sarah, Horiba, Naomi, Stayner, Lee-Anne, Siu, Lillian L., Azad, Nilofer S.
Publicado no Gynecol Oncol (2017)