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Advances in using PARP inhibitors to treat cancer
The poly (ADP-ribose) polymerase (PARP) family of enzymes plays a critical role in the maintenance of DNA integrity as part of the base excision pathway of DNA repair. PARP1 is overexpressed in a variety of cancers, and its expression has been associated with overall prognosis in cancer, especially...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3312820/ https://ncbi.nlm.nih.gov/pubmed/22401667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-10-25 |
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