Evaluation of pharmacodynamic responses to cancer therapeutic agents using DNA damage markers

PURPOSE: We sought to examine the pharmacodynamic activation of the DNA damage response (DDR) pathway in tumors following anticancer treatment for confirmation of target engagement. EXPERIMENTAL DESIGN: We evaluated the time course and spatial activation of 3 protein biomarkers of DNA damage recogni...

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Publicado no:Clin Cancer Res
Main Authors: Wilsker, Deborah F., Barrett, Allison M., Dull, Angie B., Lawrence, Scott M., Hollingshead, Melinda, Chen, Alice P., Kummar, Shivaani, Parchment, Ralph E., Doroshow, James H., Kinders, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6522288/
https://ncbi.nlm.nih.gov/pubmed/30792217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2523
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