Monitoring Drug-Induced γH2AX as a Pharmacodynamic Biomarker in Individual Circulating Tumor Cells

PURPOSE: Circulating tumor cells (CTCs) in peripheral blood of patients potentially represent a fraction of solid tumor cells available for more frequent pharmacodynamic assessment of drug action than is possible using tumor biopsy. However, currently available CTC assays are limited to cell membran...

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Autori principali: Wang, Lihua H., Pfister, Thomas D., Parchment, Ralph E., Kummar, Shivaani, Rubinstein, Larry, Evrard, Yvonne A., Gutierrez, Martin E., Murgo, Anthony J., Tomaszewski, Joseph E., Doroshow, James H., Kinders, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818670/
https://ncbi.nlm.nih.gov/pubmed/20103672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2799
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