Histone γH2AX and Poly(ADP ribose) as Clinical Pharmacodynamic Biomarkers

Tumor cells are often deficient in DNA repair and damage response (DDR) pathways, and anticancer therapies are commonly based on genotoxic treatments using radiation and/or drugs that damage DNA directly or interfere with DNA metabolism leading to the formation of DNA double-strand breaks (DSBs), an...

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Detalhes bibliográficos
Main Authors: Redon, Christophe E., Nakamura, Asako J., Zhang, Yongwei, Ji, Jiuping (Jay), Bonner, William M., Kinders, Robert, Parchment, Ralph, Doroshow, James H., Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940983/
https://ncbi.nlm.nih.gov/pubmed/20823146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0523
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