Histone γH2AX and Poly(ADP ribose) as Clinical Pharmacodynamic Biomarkers

Tumor cells are often deficient in DNA repair and damage response (DDR) pathways, and anticancer therapies are commonly based on genotoxic treatments using radiation and/or drugs that damage DNA directly or interfere with DNA metabolism leading to the formation of DNA double-strand breaks (DSBs), an...

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Main Authors: Redon, Christophe E., Nakamura, Asako J., Zhang, Yongwei, Ji, Jiuping (Jay), Bonner, William M., Kinders, Robert, Parchment, Ralph, Doroshow, James H., Pommier, Yves
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940983/
https://ncbi.nlm.nih.gov/pubmed/20823146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0523
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