Molecular Pharmacodynamics-Guided Scheduling of Biologically Effective Doses: A Drug Development Paradigm Applied to MET Tyrosine Kinase Inhibitors

The development of molecularly targeted agents has benefited from use of pharmacodynamic (PD) markers to identify “biologically effective doses” (BEDs) below maximum tolerable doses, yet this knowledge remains underutilized in selecting dosage regimens and in comparing the effectiveness of targeted...

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Vydáno v:Mol Cancer Ther
Hlavní autoři: Srivastava, Apurva K., Hollingshead, Melinda G., Govindharajulu, Jeevan P., Covey, Joseph M., Liston, Dane, Simpson, Melanie A., Peggins, James O., Bottaro, Donald P., Wright, John J., Kinders, Robert J., Doroshow, James H., Parchment, Ralph E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935559/
https://ncbi.nlm.nih.gov/pubmed/29444985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0552
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