Effective implementation of novel MET pharmacodynamic assays in translational studies

MET tyrosine kinase (TK) dysregulation is significantly implicated in many types of cancer. Despite over 20 years of drug development to target MET in cancers, a pure anti-MET therapeutic has not yet received market approval. The failure of two recently concluded phase III trials point to a major we...

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Detalles Bibliográficos
Publicado en:Ann Transl Med
Main Authors: Srivastava, Apurva K., Navas, Tony, Herrick, William G., Hollingshead, Melinda G., Bottaro, Donald P., Doroshow, James H., Parchment, Ralph E.
Formato: Artigo
Idioma:Inglês
Publicado: AME Publishing Company 2017
Assuntos:
Review Article on MET as Actionable Target in Cancer Therapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253289/
https://ncbi.nlm.nih.gov/pubmed/28164088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2016.12.78
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