Inhibition of carboplatin-induced DNA interstrand crosslink repair by gemcitabine in patients receiving these drugs for ‘platinum-resistant’ ovarian cancer

Por Ledermann, Jonathan A, Gabra, Hani, Jayson, Gordon C, Spanswick, Victoria J, Rustin, Gordon JS, Jitlal, Mark, James, Lindsay E, Hartley, John A
Publicado no Clin Cancer Res (2010)

γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from two Phase I clinical trials of SJG-136 (SG2000)

Por Wu, Jenny, Clingen, Peter H, Spanswick, Victoria J, Mellinas-Gomez, Maria, Meyer, Tim, Puzanov, Igor, Jodrell, Duncan, Hochhauser, Daniel, Hartley, John A
Publicado no Clin Cancer Res (2012)

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

Por Cook, Rebecca, Zoumpoulidou, Georgia, Luczynski, Maciej T., Rieger, Simone, Moquet, Jayne, Spanswick, Victoria J., Hartley, John A., Rothkamm, Kai, Huang, Paul H., Mittnacht, Sibylle
Publicado no Cell Rep (2015)

Evidence for different mechanisms of ‘unhooking’ for melphalan and cisplatin-induced DNA interstrand cross-links <it>in vitro</it> and in clinical acquired resistant tumour samples...

Por Spanswick Victoria J, Lowe Helen L, Newton Claire, Bingham John P, Bagnobianchi Alessia, Kiakos Konstantinos, Craddock Charles, Ledermann Jonathan A, Hochhauser Daniel, Hartley John A
Publicado em 2012-09-01

Evidence for different mechanisms of ‘unhooking’ for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples

Por Spanswick, Victoria J, Lowe, Helen L, Newton, Claire, Bingham, John P, Bagnobianchi, Alessia, Kiakos, Konstantinos, Craddock, Charles, Ledermann, Jonathan A, Hochhauser, Daniel, Hartley, John A
Publicado em 2012

Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

Por Ip, Laura R. H., Poulogiannis, George, Viciano, Felipe Cia, Sasaki, Junko, Kofuji, Satoshi, Spanswick, Victoria J., Hochhauser, Daniel, Hartley, John A., Sasaki, Takehiko, Gewinner, Christina A.
Publicado no Oncotarget (2015)

Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours

Por Mellinas-Gomez, Maria, Spanswick, Victoria J., Paredes-Moscosso, Solange R., Robson, Matthew, Pedley, R. Barbara, Thurston, David E., Baines, Stephen J., Stell, Anneliese, Hartley, John A.
Publicado no BMC Vet Res (2015)

Phase I, Pharmacokinetic and Pharmacodynamic Study of SJG-136, a Novel DNA Sequence Selective Minor Groove Cross-Linking Agent, in advanced solid tumors

Por Puzanov, Igor, Lee, Wooin, Chen, Alice P., Calcutt, M. Wade, Hachey, David. L., Vermeulen, Wendy L., Spanswick, Victoria J., Liao, Chih-Yi, Hartley, John A., Berlin, Jordan D., Rothenberg, Mace L.
Publicado em 2011