EGFR NUCLEAR TRANSLOCATION MODULATES DNA REPAIR FOLLOWING CISPLATIN AND IONIZING RADIATION TREATMENT

Por Liccardi, Gianmaria, Hartley, John A, Hochhauser, Daniel
Publicado em 2011

Repair of Intermediate Structures Produced at DNA Interstrand Cross-Links in Saccharomyces cerevisiae

Por McHugh, Peter J., Sones, William R., Hartley, John A.
Publicado em 2000

A 96-well DNase I footprinting screen for drug–DNA interactions

Por Ellis, Tom, Evans, David A., Martin, Christopher R. H., Hartley, John A.
Publicado em 2007

DNA Interstrand Cross-Link Repair in the Saccharomyces cerevisiae Cell Cycle: Overlapping Roles for PSO2 (SNM1) with MutS Factors and EXO1 during S Phase

Por Barber, Louise J., Ward, Thomas A., Hartley, John A., McHugh, Peter J.
Publicado em 2005

Defining the Roles of Nucleotide Excision Repair and Recombination in the Repair of DNA Interstrand Cross-Links in Mammalian Cells

Por De Silva, Inusha U., McHugh, Peter J., Clingen, Peter H., Hartley, John A.
Publicado em 2000

Defects in interstrand cross-link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin

Por De Silva, Inusha U., McHugh, Peter J., Clingen, Peter H., Hartley, John A.
Publicado em 2002

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

Por Tomas, Alejandra, Vaughan, Simon O., Burgoyne, Thomas, Sorkin, Alexander, Hartley, John A., Hochhauser, Daniel, Futter, Clare E.
Publicado no Nat Commun (2015)

DNA-binding properties of new fluorescent AzaHx-amides: Methoxy-pyridyl-aza-benzimidazole-pyrrole-imidazole/pyrrole

Por Liu, Beibei, Pett, Luke, Kiakos, Konstantinos, Patil, Pravin, Satam, Vijay, Hartley, John A., Lee, Moses, Wilson, W.David
Publicado no Chembiochem (2018)

Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR

Por Garelnabi, Elrashied A. E., Pletsas, Dimitrios, Li, Li, Kiakos, Konstantinos, Karodia, Nazira, Hartley, John A., Phillips, Roger M., Wheelhouse, Richard T.
Publicado em 2012

Polyamide Curvature and DNA Sequence Selective Recognition: Use of 4-Aminobenzamide to Adjust Curvature

Por Lajiness, Jamie, Sielaff, Alan, Mackay, Hilary, Brown, Toni, Kluza, Jerome, Nguyen, Binh, Wilson, W. David, Lee, Moses, Hartley, John A.
Publicado em 2009

NF-Y activates genes of metabolic pathways altered in cancer cells

Por Benatti, Paolo, Chiaramonte, Maria Luisa, Lorenzo, Mariangela, Hartley, John A., Hochhauser, Daniel, Gnesutta, Nerina, Mantovani, Roberto, Imbriano, Carol, Dolfini, Diletta
Publicado no Oncotarget (2015)

Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer

Por Santoro, Valeria, Jia, Ruochen, Thompson, Hannah, Nijhuis, Anke, Jeffery, Rosemary, Kiakos, Konstantinos, Silver, Andrew R., Hartley, John A., Hochhauser, Daniel
Publicado no J Natl Cancer Inst (2015)

Schizosaccharomyces pombe Checkpoint Response to DNA Interstrand Cross-Links

Por Lambert, Sarah, Mason, Sarah J., Barber, Louise J., Hartley, John A., Pearce, Jackie A., Carr, Anthony M., McHugh, Peter J.
Publicado em 2003

Energetic basis for selective recognition of T·G mismatched base pairs in DNA by imidazole-rich polyamides

Por Lacy, Eilyn R., Nguyen, Binh, Le, Minh, Cox, Kari K., O'Hare, Caroline, Hartley, John A., Lee, Moses, Wilson, W. David
Publicado em 2004

Inhibition of carboplatin-induced DNA interstrand crosslink repair by gemcitabine in patients receiving these drugs for ‘platinum-resistant’ ovarian cancer

Por Ledermann, Jonathan A, Gabra, Hani, Jayson, Gordon C, Spanswick, Victoria J, Rustin, Gordon JS, Jitlal, Mark, James, Lindsay E, Hartley, John A
Publicado no Clin Cancer Res (2010)

γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from two Phase I clinical trials of SJG-136 (SG2000)

Por Wu, Jenny, Clingen, Peter H, Spanswick, Victoria J, Mellinas-Gomez, Maria, Meyer, Tim, Puzanov, Igor, Jodrell, Duncan, Hochhauser, Daniel, Hartley, John A
Publicado no Clin Cancer Res (2012)

DNA sequence recognition in the minor groove by crosslinked polyamides: The effect of N-terminal head group and linker length on binding affinity and specificity

Por O'Hare, C. Caroline, Mack, Darcy, Tandon, Manju, Sharma, Sanjay K., Lown, J. William, Kopka, Mary L., Dickerson, Richard E., Hartley, John A.
Publicado em 2002

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]be...

Por Clingen, Peter H., De Silva, Inusha U., McHugh, Peter J., Ghadessy, Farid J, Tilby, Michael J., Thurston, David E., Hartley, John A.
Publicado em 2005

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining

Por Cook, Rebecca, Zoumpoulidou, Georgia, Luczynski, Maciej T., Rieger, Simone, Moquet, Jayne, Spanswick, Victoria J., Hartley, John A., Rothkamm, Kai, Huang, Paul H., Mittnacht, Sibylle
Publicado no Cell Rep (2015)

Expression of somatostatin receptors 2 and 5 in circulating tumour cells from patients with neuroendocrine tumours

Por Childs, Alexa, Vesely, Clare, Ensell, Leah, Lowe, Helen, Luong, Tu Vinh, Caplin, Martyn E, Toumpanakis, Christos, Thirlwell, Christina, Hartley, John A, Meyer, Tim
Publicado no Br J Cancer (2016)