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EGFR NUCLEAR TRANSLOCATION MODULATES DNA REPAIR FOLLOWING CISPLATIN AND IONIZING RADIATION TREATMENT

EGFR overexpression is associated with resistance to chemotherapy and radiotherapy. EGFR modulates DNA repair after radiation-induced damage through association with the catalytic subunit of DNA protein kinase (DNA-PKcs). We investigated the role of EGFR nuclear import and its association with DNAPK...

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Hlavní autoři: Liccardi, Gianmaria, Hartley, John A, Hochhauser, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033323/
https://ncbi.nlm.nih.gov/pubmed/21266349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2384
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