Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

Treatment options for ovarian cancer patients remain limited and overall survival is less than 50% despite recent clinical advances. The lipid phosphatase inositol polyphosphate 4-phosphatase type II (INPP4B) has been described as a tumor suppressor in the PI3K/Akt pathway with loss of expression fo...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Ip, Laura R. H., Poulogiannis, George, Viciano, Felipe Cia, Sasaki, Junko, Kofuji, Satoshi, Spanswick, Victoria J., Hochhauser, Daniel, Hartley, John A., Sasaki, Takehiko, Gewinner, Christina A.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4496374/
https://ncbi.nlm.nih.gov/pubmed/25868852
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