GTP metabolic reprogramming by IMPDH2: unlocking cancer cells’ fuelling mechanism

di Kofuji, Satoshi, Sasaki, Atsuo T
Pubblicato in J Biochem (2020)

Dynamic Compartmentalization of Purine Nucleotide Metabolic Enzymes at Leading Edge in Highly Motile Renal Cell Carcinoma

di Wolfe, Kara, Kofuji, Satoshi, Yoshino, Hirofumi, Sasaki, Mika, Okumura, Koichi, Sasaki, Atsuo T.
Pubblicato in Biochem Biophys Res Commun (2019)

Structural reverse genetics study of the PI5P4Kβ–nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cells

di Takeuchi, Koh, Senda, Miki, Lo, Yu-Hua, Kofuji, Satoshi, Ikeda, Yoshiki, Sasaki, Atsuo T., Senda, Toshiya
Pubblicato in FEBS J (2016)

microRNA-210-3p depletion by CRISPR/Cas9 promoted tumorigenesis through revival of TWIST1 in renal cell carcinoma

di Yoshino, Hirofumi, Yonemori, Masaya, Miyamoto, Kazutaka, Tatarano, Syuichi, Kofuji, Satoshi, Nohata, Nijiro, Nakagawa, Masayuki, Enokida, Hideki
Pubblicato in Oncotarget (2017)

MKK7 deficiency in mature neurons impairs parental behavior in mice

di Shin, Tadashi, Hiraoka, Yuichi, Yamasaki, Tokiwa, Marth, Jamey D., Penninger, Josef M., Kanai‐Azuma, Masami, Tanaka, Kohichi, Kofuji, Satoshi, Nishina, Hiroshi
Pubblicato in Genes Cells (2020)

PHGDH as a key enzyme for serine biosynthesis in HIF2α-targeting therapy for renal cell carcinoma

di Yoshino, Hirofumi, Nohata, Nijiro, Miyamoto, Kazutaka, Yonemori, Masaya, Sakaguchi, Takashi, Sugita, Satoshi, Itesako, Toshihiko, Kofuji, Satoshi, Nakagawa, Masayuki, Dahiya, Rajvir, Enokida, Hideki
Pubblicato in Cancer Res (2017)

Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story

di Naffouje, Rand, Grover, Punita, Yu, Hongyang, Sendilnathan, Arun, Wolfe, Kara, Majd, Nazanin, Smith, Eric P., Takeuchi, Koh, Senda, Toshiya, Kofuji, Satoshi, Sasaki, Atsuo T.
Pubblicato in Cancers (Basel) (2019)

Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

di Ip, Laura R. H., Poulogiannis, George, Viciano, Felipe Cia, Sasaki, Junko, Kofuji, Satoshi, Spanswick, Victoria J., Hochhauser, Daniel, Hartley, John A., Sasaki, Takehiko, Gewinner, Christina A.
Pubblicato in Oncotarget (2015)

Prostaglandin E(2) and its receptor EP2 trigger signaling that contributes to YAP‐mediated cell competition

di Ishihara, Erika, Nagaoka, Yuya, Okuno, Toshiaki, Kofuji, Satoshi, Ishigami‐Yuasa, Mari, Kagechika, Hiroyuki, Kamimura, Kenya, Terai, Shuji, Yokomizo, Takehiko, Sugimoto, Yukihiko, Fujita, Yasuyuki, Suzuki, Akira, Nishina, Hiroshi
Pubblicato in Genes Cells (2020)

Pharmacologic targeting of S6K1 in PTEN-deficient neoplasia

di Liu, Hongqi, Feng, Xizhi, Ennis, Kelli N., Behrmann, Catherine A., Sarma, Pranjal, Jiang, Tony T., Kofuji, Satoshi, Niu, Liang, Stratton, Yiwen, Thomas, Hala Elnakat, Yoon, Sang-Oh, Sasaki, Atsuo T., Plas, David R.
Pubblicato in Cell Rep (2017)

CBIO-37 DYNAMIC ROLE OF GTP-ENERGY METABOLISM IN GLIOMAGENESIS: DIAGNOSTIC AND THERAPEUTIC APPLICATIONS

di Kofuji, Satoshi, Warren, Mikako, Sumita, Kazutaka, Hirayama, Akiyoshi, Ramkissoon, Annmarie, Malhotra, Akshiv, Yoshino, Hirofumi, Pater, Luke, Gozal, Yair, Gogela, Steven, Kendler, Ady, Wise, Trisha, Curry, Richard, Warnick, Ronald, Wakimoto, Hiroaki, DasGupta, Biplab, Chow, Lionel, Soga, Tomoyoshi, Horbinski, Craig, Sasaki, Atsuo
Pubblicato in Neuro Oncol (2015)

Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine

di Takasuga, Shunsuke, Horie, Yasuo, Sasaki, Junko, Sun-Wada, Ge-Hong, Kawamura, Nobuyuki, Iizuka, Ryota, Mizuno, Katsunori, Eguchi, Satoshi, Kofuji, Satoshi, Kimura, Hirotaka, Yamazaki, Masakazu, Horie, Chihoko, Odanaga, Eri, Sato, Yoshiko, Chida, Shinsuke, Kontani, Kenji, Harada, Akihiro, Katada, Toshiaki, Suzuki, Akira, Wada, Yoh, Ohnishi, Hirohide, Sasaki, Takehiko
Pubblicazione 2013

The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis

di Sumita, Kazutaka, Lo, Yu-Hua, Takeuchi, Koh, Senda, Miki, Kofuji, Satoshi, Ikeda, Yoshiki, Terakawa, Jumpei, Sasaki, Mika, Yoshino, Hirofumi, Majd, Nazanin, Zheng, Yuxiang, Kahoud, Emily Rose, Yokota, Takehiro, Emerling, Brooke M., Asara, John M., Ishida, Tetsuo, Locasale, Jason W., Daikoku, Takiko, Anastasiou, Dimitrios, Senda, Toshiya, Sasaki, Atsuo T.
Pubblicato in Mol Cell (2016)

Identification of lysine methylation in the core GTPase domain by GoMADScan

di Yoshino, Hirofumi, Yin, Guowei, Kawaguchi, Risa, Popov, Konstantin I., Temple, Brenda, Sasaki, Mika, Kofuji, Satoshi, Wolfe, Kara, Kofuji, Kaori, Okumura, Koichi, Randhawa, Jaskirat, Malhotra, Akshiv, Majd, Nazanin, Ikeda, Yoshiki, Shimada, Hiroko, Kahoud, Emily Rose, Haviv, Sasson, Iwase, Shigeki, Asara, John M., Campbell, Sharon L., Sasaki, Atsuo T.
Pubblicato in PLoS One (2019)

Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan

di Yoshino, Hirofumi, Yin, Guowei, Kawaguchi, Risa, Popov, Konstantin I., Temple, Brenda, Sasaki, Mika, Kofuji, Satoshi, Wolfe, Kara, Kofuji, Kaori, Okumura, Koichi, Randhawa, Jaskirat, Malhotra, Akshiv, Majd, Nazanin, Ikeda, Yoshiki, Shimada, Hiroko, Kahoud, Emily Rose, Haviv, Sasson, Iwase, Shigeki, Asara, John M., Campbell, Sharon L., Sasaki, Atsuo T.
Pubblicato in PLoS One (2019)

Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

di Kim, Seong M., Roy, Saurabh G., Chen, Bin, Nguyen, Tiffany M., McMonigle, Ryan J., McCracken, Alison N., Zhang, Yanling, Kofuji, Satoshi, Hou, Jue, Selwan, Elizabeth, Finicle, Brendan T., Nguyen, Tricia T., Ravi, Archna, Ramirez, Manuel U., Wiher, Tim, Guenther, Garret G., Kono, Mari, Sasaki, Atsuo T., Weisman, Lois S., Potma, Eric O., Tromberg, Bruce J., Edwards, Robert A., Hanessian, Stephen, Edinger, Aimee L.
Pubblicato in J Clin Invest (2016)

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

di Kofuji, Satoshi, Hirayama, Akiyoshi, Eberhardt, Alexander Otto, Kawaguchi, Risa, Sugiura, Yuki, Sampetrean, Oltea, Ikeda, Yoshiki, Warren, Mikako, Sakamoto, Naoya, Kitahara, Shuji, Yoshino, Hirofumi, Yamashita, Daisuke, Sumita, Kazutaka, Wolfe, Kara, Lange, Lisa, Ikeda, Satsuki, Shimada, Hiroko, Minami, Noriaki, Malhotra, Akshiv, Morioka, Shin, Ban, Yuki, Asano, Maya, Flanary, Victoria L, Ramkissoon, Annmarie, Chow, Lionel M.L., Kiyokawa, Juri, Mashimo, Tomoyuki, Lucey, Greg, Mareninov, Sergey, Ozawa, Tatsuya, Onishi, Nobuyuki, Okumura, Koichi, Terakawa, Jumpei, Daikoku, Takiko, Wise-Draper, Trisha, Majd, Nazanin, Kofuji, Kaori, Sasaki, Mika, Mori, Masaru, Kanemura, Yonehiro, Smith, Eric P., Anastasiou, Dimitrios, Wakimoto, Hiroaki, Holland, Eric C., Yong, William H., Horbinski, Craig, Nakano, Ichiro, DeBerardinis, Ralph J., Bachoo, Robert M., Mischel, Paul S., Yasui, Wataru, Suematsu, Makoto, Saya, Hideyuki, Soga, Tomoyoshi, Grummt, Ingrid, Bierhoff, Holger, Sasaki, Atsuo T.
Pubblicato in Nat Cell Biol (2019)