Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

Oncogenic mutations drive anabolic metabolism, creating a dependency on nutrient influx through transporters, receptors, and macropinocytosis. While sphingolipids suppress tumor growth by downregulating nutrient transporters, macropinocytosis and autophagy still provide cancer cells with fuel. Thera...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kim, Seong M., Roy, Saurabh G., Chen, Bin, Nguyen, Tiffany M., McMonigle, Ryan J., McCracken, Alison N., Zhang, Yanling, Kofuji, Satoshi, Hou, Jue, Selwan, Elizabeth, Finicle, Brendan T., Nguyen, Tricia T., Ravi, Archna, Ramirez, Manuel U., Wiher, Tim, Guenther, Garret G., Kono, Mari, Sasaki, Atsuo T., Weisman, Lois S., Potma, Eric O., Tromberg, Bruce J., Edwards, Robert A., Hanessian, Stephen, Edinger, Aimee L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096903/
https://ncbi.nlm.nih.gov/pubmed/27669461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87148
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