Loss of TSC2 confers resistance to ceramide and nutrient deprivation

Nutrient stress that produces quiescence and catabolism in normal cells is lethal to cancer cells because oncogenic mutations constitutively drive anabolism. One driver of biosynthesis in cancer cells is the mTORC1 signaling complex. Activating mTORC1 by deleting its negative regulator TSC2 leads to...

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Autors principals: Guenther, Garret G., Liu, Gang, Ramirez, Manuel U., McMonigle, Ryan J., Kim, Seong M., McCracken, Alison N., Joo, Yoosun, Ushach, Irina, Nguyen, Natalie L., Edinger, Aimee L.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858574/
https://ncbi.nlm.nih.gov/pubmed/23604129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.139
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