Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways

Oncogenic mutations drive anabolic metabolism, creating a dependency on nutrient influx through transporters, receptors, and macropinocytosis. While sphingolipids suppress tumor growth by downregulating nutrient transporters, macropinocytosis and autophagy still provide cancer cells with fuel. Thera...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Kim, Seong M., Roy, Saurabh G., Chen, Bin, Nguyen, Tiffany M., McMonigle, Ryan J., McCracken, Alison N., Zhang, Yanling, Kofuji, Satoshi, Hou, Jue, Selwan, Elizabeth, Finicle, Brendan T., Nguyen, Tricia T., Ravi, Archna, Ramirez, Manuel U., Wiher, Tim, Guenther, Garret G., Kono, Mari, Sasaki, Atsuo T., Weisman, Lois S., Potma, Eric O., Tromberg, Bruce J., Edwards, Robert A., Hanessian, Stephen, Edinger, Aimee L.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096903/
https://ncbi.nlm.nih.gov/pubmed/27669461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87148
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