Pharmacologic targeting of S6K1 in PTEN-deficient neoplasia

Genetic S6K1 inactivation can induce apoptosis in PTEN-deficient cells. We analyzed the therapeutic potential of S6K1 inhibitors in PTEN-deficient T cell leukemia and glioblastoma. Results revealed that the S6K1 inhibitor LY-2779964 was relatively ineffective as a single agent, while S6K1-targeting...

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Publicat a:Cell Rep
Autors principals: Liu, Hongqi, Feng, Xizhi, Ennis, Kelli N., Behrmann, Catherine A., Sarma, Pranjal, Jiang, Tony T., Kofuji, Satoshi, Niu, Liang, Stratton, Yiwen, Thomas, Hala Elnakat, Yoon, Sang-Oh, Sasaki, Atsuo T., Plas, David R.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374978/
https://ncbi.nlm.nih.gov/pubmed/28249155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.022
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