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CBMT-16. A COMBINATION STRATEGY TO COUNTERACT PTEN-DEFICIENCY BY TARGETING THE S6 AND TAM KINASES IN GLIOBLASTOMA
PTEN deficiency affects the majority of glioblastomas, triggering signal transduction pathways that induce anabolic metabolism and apoptosis resistance. The mTOR complex 1 (mTORC1) and S6 kinases (S6Ks) are key mediators of metabolic reprogramming and apoptosis resistance in PTEN-deficient cells. S6...
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| Publicado no: | Neuro Oncol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6217018/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.135 |
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