CBMT-16. A COMBINATION STRATEGY TO COUNTERACT PTEN-DEFICIENCY BY TARGETING THE S6 AND TAM KINASES IN GLIOBLASTOMA

PTEN deficiency affects the majority of glioblastomas, triggering signal transduction pathways that induce anabolic metabolism and apoptosis resistance. The mTOR complex 1 (mTORC1) and S6 kinases (S6Ks) are key mediators of metabolic reprogramming and apoptosis resistance in PTEN-deficient cells. S6...

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Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Ennis, Kelli, Sarma, Pranjal, Wetzel, Collin, A. Behrmann, Catherine, Plas, David
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217018/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.135
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