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CSIG-05. S6K FEEDBACK REGULATION OF THE RECEPTOR TYROSINE KINASE AXL IN PTEN-DEFICIENT GLIOBLASTOMA
Glioblastoma multiforme (GBM), the most aggressive type of malignant brain cancer in adults, harbors frequent mutations and/or deletions in the tumor suppressor gene PTEN leading to therapeutic resistance. In PTEN-deficient GBM, mTOR complex 1 (mTORC1) and the S6 kinases (S6Ks) mediate increased met...
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| Publicado en: | Neuro Oncol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7650363/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.117 |
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