Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency

Pten inactivation promotes cell survival in leukemia cells by activating glycolytic metabolism. We found that targeting ribosomal protein S6 kinase 1 (S6K1) in Pten-deficient cells suppressed glycolysis and induced apoptosis. S6K1 knockdown decreased expression of HIF-1α, and HIF-1α was sufficient t...

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Detaylı Bibliyografya
Asıl Yazarlar: Tandon, Preeti, Gallo, Catherine A., Khatri, Shikha, Barger, Jennifer F., Yepiskoposyan, Hasmik, Plas, David R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038712/
https://ncbi.nlm.nih.gov/pubmed/21262837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013629108
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