Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story

The purine nucleotides ATP and GTP are essential precursors to DNA and RNA synthesis and fundamental for energy metabolism. Although de novo purine nucleotide biosynthesis is increased in highly proliferating cells, such as malignant tumors, it is not clear if this is merely a secondary manifestatio...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Naffouje, Rand, Grover, Punita, Yu, Hongyang, Sendilnathan, Arun, Wolfe, Kara, Majd, Nazanin, Smith, Eric P., Takeuchi, Koh, Senda, Toshiya, Kofuji, Satoshi, Sasaki, Atsuo T.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6770829/
https://ncbi.nlm.nih.gov/pubmed/31514446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11091346
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