Phase I, Pharmacokinetic and Pharmacodynamic Study of SJG-136, a Novel DNA Sequence Selective Minor Groove Cross-Linking Agent, in advanced solid tumors

PURPOSE: This phase I study assessed the maximum tolerated dose (MTD), safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of SJG-136, a sequence-specific DNA cross-linking agent, in patients with advanced cancer. EXPERIMENTAL DESIGN: In Schedule A, seven patients received escalati...

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Detalhes bibliográficos
Main Authors: Puzanov, Igor, Lee, Wooin, Chen, Alice P., Calcutt, M. Wade, Hachey, David. L., Vermeulen, Wendy L., Spanswick, Victoria J., Liao, Chih-Yi, Hartley, John A., Berlin, Jordan D., Rothenberg, Mace L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107910/
https://ncbi.nlm.nih.gov/pubmed/21346148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2056
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