Preclinical Pharmacokinetics Study of R- and S-Enantiomers of the Histone Deacetylase Inhibitor, AR-42 (NSC 731438), in Rodents

AR-42, a new orally bioavailable, potent, hydroxamate-tethered phenylbutyrate class I/IIB histone deacetylase inhibitor currently is under evaluation in phase 1 and 2 clinical trials and has demonstrated activity in both hematologic and solid tumor malignancies. This report focuses on the preclinica...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: Cheng, Hao, Xie, Zhiliang, Jones, William P., Wei, Xiaohui Tracey, Liu, Zhongfa, Wang, Dasheng, Kulp, Samuel K., Wang, Jiang, Coss, Christopher C., Chen, Ching-Shih, Marcucci, Guido, Garzon, Ramiro, Covey, Joseph M., Phelps, Mitch A., Chan, Kenneth K.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256597/
https://ncbi.nlm.nih.gov/pubmed/26943915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-016-9876-3
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