Oral and intravenous pharmacokinetics of 5-fluoro-2’-deoxycytidine and THU in cynomolgus monkeys and humans

INTRODUCTION: 5-Fluoro-2’-deoxycytidine (FdCyd; NSC48006), a fluoropyrimidine nucleoside inhibitor of DNA methylation, is degraded by cytidine deaminase (CD). Pharmacokinetic evaluation was carried out in cynomolgus monkeys in support of an ongoing phase I study of the PO combination of FdCyd and th...

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Publicado no:Cancer Chemother Pharmacol
Main Authors: Holleran, Julianne L., Beumer, Jan H., McCormick, David L., Johnson, William D., Newman, Edward M., Doroshow, James H., Kummar, Shivaani, Covey, Joseph M., Davis, Myrtle, Eiseman, Julie L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573928/
https://ncbi.nlm.nih.gov/pubmed/26321472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2857-x
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