Biodistribution, Tumor Detection, and Radiation Dosimetry of (18)F-5-Fluoro-2′-Deoxycytidine with Tetrahydrouridine in Solid Tumors

In preclinical studies, 5-fluoro-2′-deoxycytidine (FdCyd), an inhibitor of DNA methyltransferase and DNA hypermethylation, has shown treatment efficacy against multiple malignancies by suppressing epigenetic hypermethylation in tumor cells. Several ongoing clinical trials are using FdCyd, and althou...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Nucl Med
Auteurs principaux: Young, Colin R., Adler, Stephen, Eary, Janet F., Lindenberg, M. Liza, Jacobs, Paula M., Collins, Jerry, Kummar, Shivaani, Kurdziel, Karen A., Choyke, Peter L., Mena, Esther
Format: Artigo
Langue:Inglês
Publié: Society of Nuclear Medicine 2019
Sujets:
Oncology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448462/
https://ncbi.nlm.nih.gov/pubmed/30389817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.118.216994
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