Biodistribution, Tumor Detection, and Radiation Dosimetry of (18)F-5-Fluoro-2′-Deoxycytidine with Tetrahydrouridine in Solid Tumors

In preclinical studies, 5-fluoro-2′-deoxycytidine (FdCyd), an inhibitor of DNA methyltransferase and DNA hypermethylation, has shown treatment efficacy against multiple malignancies by suppressing epigenetic hypermethylation in tumor cells. Several ongoing clinical trials are using FdCyd, and althou...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Young, Colin R., Adler, Stephen, Eary, Janet F., Lindenberg, M. Liza, Jacobs, Paula M., Collins, Jerry, Kummar, Shivaani, Kurdziel, Karen A., Choyke, Peter L., Mena, Esther
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6448462/
https://ncbi.nlm.nih.gov/pubmed/30389817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.118.216994
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